1-磷酸鞘氨醇在癌症中作用的新视角
New perspectives on the role of sphingosine 1-phosphate in cancer.
作者信息
Pyne Susan, Pyne Nigel J
机构信息
University of Strathclyde, Glasgow, UK.
出版信息
Handb Exp Pharmacol. 2013(216):55-71. doi: 10.1007/978-3-7091-1511-4_3.
PMID:23563651
Abstract
In this chapter, we review the latest developments concerning the role of sphingosine 1-phosphate (S1P) in cancer. Particular focus is paid to the role of sphingosine kinases 1 and 2, S1P lyase and S1P-dependent signalling networks in both solid tumours and haematological cancer. The potential of this S1P-dependent pathophysiology as a therapeutic target for the treatment of cancer is also discussed.
摘要
在本章中，我们回顾了关于1-磷酸鞘氨醇（S1P）在癌症中作用的最新进展。特别关注鞘氨醇激酶1和2、S1P裂解酶以及S1P依赖性信号网络在实体瘤和血液系统癌症中的作用。我们还讨论了这种S1P依赖性病理生理学作为癌症治疗靶点的潜力。
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