鞘氨醇激酶1作为抗癌治疗靶点。
Sphingosine kinase 1 as an anticancer therapeutic target.
作者信息
Gao Ying, Gao Fei, Chen Kan, Tian Mei-li, Zhao Dong-li
机构信息
Department of Radiotherapy Oncology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Department of Neurology, First Affiliated Hospital of Xi'an Medical University, Xi'an, People's Republic of China.
出版信息
Drug Des Devel Ther. 2015 Jun 23;9:3239-45. doi: 10.2147/DDDT.S83288. eCollection 2015.
Abstract
The development of chemotherapeutic resistance is a major challenge in oncology. Elevated sphingosine kinase 1 (SK1) levels is predictive of a poor prognosis, and SK1 overexpression may confer resistance to chemotherapeutics. The SK/sphingosine-1-phosphate (S1P)/sphingosine-1-phosphate receptor (S1PR) signaling pathway has been implicated in the progression of various cancers and in chemotherapeutic drug resistance. Therefore, SK1 may represent an important target for cancer therapy. Targeting the SK/S1P/S1PR signaling pathway may be an effective anticancer therapeutic strategy, particularly in the context of overcoming drug resistance. This review summarizes our current understanding of the role of SK/S1P/S1PR signaling in cancer and development of SK1 inhibitors.
摘要
化疗耐药性的产生是肿瘤学中的一项重大挑战。鞘氨醇激酶1（SK1）水平升高预示着预后不良，且SK1过表达可能导致对化疗药物产生耐药性。SK/鞘氨醇-1-磷酸（S1P）/鞘氨醇-1-磷酸受体（S1PR）信号通路与多种癌症的进展及化疗耐药性有关。因此，SK1可能是癌症治疗的一个重要靶点。针对SK/S1P/S1PR信号通路可能是一种有效的抗癌治疗策略，尤其是在克服耐药性方面。本综述总结了我们目前对SK/S1P/S1PR信号在癌症中的作用以及SK1抑制剂的研发情况的理解。
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