Takeuchi Satoru, Nagatani Kimihiro, Wada Kojiro, Nawashiro Hiroshi, Otani Naoki, Osada Hideo, Kobayashi Hiroaki, Suzuki Takamoto, Shima Katsuji
Department of Neurosurgery, National Defense Medical College, Tokorozawa, Japan.
Acta Neurochir Suppl. 2013;118:281-3. doi: 10.1007/978-3-7091-1434-6_54.
Decompressive craniectomy (DC) is an established therapeutic option following severe traumatic brain injury (TBI). However, several delayed complications of DC have been reported, including ventriculomegaly, which can lead to poor patient outcomes. Nevertheless, ventriculomegaly can occur after TBI even without DC. The aim of the present study was to investigate the influence of DC on ventriculomegaly.
Adult male Sprague-Dawley rats (300-400 g) were subjected to lateral fluid percussion injury using a fluid percussion device. Rats were randomly divided into four groups: sham, craniectomized without trauma (D group), traumatized without DC (FPI group), and craniectomized immediately after trauma (FPI + D group). On day 28 of recovery, ventricular volumes were measured by image analysis.
There was no significant difference in ventricular size between the sham group and the D group animals or between the FPI group and the FPI + D group animals.
These data suggest that DC may not be a risk factor for ventriculomegaly after TBI.
减压性颅骨切除术（DC）是重度创伤性脑损伤（TBI）后的一种既定治疗选择。然而，已有报道称DC存在多种延迟并发症，包括脑室扩大，这可能导致患者预后不良。尽管如此，即使没有进行DC，TBI后也可能发生脑室扩大。本研究的目的是探讨DC对脑室扩大的影响。
成年雄性Sprague-Dawley大鼠（300 - 400克）使用液压冲击装置进行侧方液压冲击损伤。大鼠被随机分为四组：假手术组、未受创伤行颅骨切除组（D组）、受创伤未行DC组（FPI组）和创伤后立即行颅骨切除组（FPI + D组）。在恢复的第28天，通过图像分析测量脑室体积。
假手术组与D组动物之间以及FPI组与FPI + D组动物之间的脑室大小无显著差异。
这些数据表明，DC可能不是TBI后脑室扩大的危险因素。
