Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Int J Cancer. 2013 Oct 15;133(8):1867-75. doi: 10.1002/ijc.28196. Epub 2013 May 8.
Little is known about the role of association between ABO blood group and development of extrahepatic cholangiocarcinoma (ECC) through effects on hepatitis B viral (HBV) infection. Our aim was to address this question using a matched case-control study in Southern China.We prospectively analyzed 239 ECC patients, and 478 age- and sex-matched controls in Sun Yat-sen Memorial Hospital of Sun Yat-sen University from 1999 to 2011. Information on ABO blood group, HBV infection and other clinicopathologic factors was collected. Adjusted odds ratios (AORs) and the corresponding 95% confidence intervals (CIs) were computed from unconditional logistic regression models, adjusted for major confounding factors. The estimated AORs were as follows: A blood group, 1.784; HBsAg+/HbcAb+, 1.848 and HBsAg-/HbcAb+, 1.501. The A blood type had a significant effect on modifying the risk of ECC among subjects with HBsAg+/HbcAb+ (AOR 3.795, 95% CI 1.427-10.090). ECC patients with A blood group were more common in younger subjects, and a lower proportion of serum CA-125 and CA19-9 elevation in patients with blood type A was found. Our study suggests an association between A blood type, HBV infection and ECC risk, and a synergism between A blood type and HBV infection in the development of ECC.
目前已知的关于 ABO 血型与肝外胆管癌（ECC）发展之间的关系主要是通过对乙型肝炎病毒（HBV）感染的影响。我们旨在通过在中国南方进行的一项匹配病例对照研究来解决这个问题。
我们前瞻性地分析了 1999 年至 2011 年中山大学孙逸仙纪念医院的 239 名 ECC 患者和 478 名年龄和性别匹配的对照。收集了 ABO 血型、HBV 感染和其他临床病理因素的信息。使用非条件 logistic 回归模型调整主要混杂因素后，计算调整后的优势比（AOR）及其相应的 95%置信区间（CI）。估计的 AOR 如下：A 血型，1.784；HBsAg+/HbcAb+，1.848；HBsAg-/HbcAb+，1.501。A 血型对 HBsAg+/HbcAb+ 患者的 ECC 风险有显著影响（AOR3.795，95%CI1.427-10.090）。A 血型的 ECC 患者更常见于年轻患者，并且 A 血型患者的血清 CA-125 和 CA19-9 升高的比例较低。
我们的研究表明 A 血型、HBV 感染与 ECC 风险之间存在关联，并且 A 血型与 HBV 感染在 ECC 的发展中存在协同作用。
