Bassyouni Iman H, Gamal Sherif, Talaat Roba M, Siam Ibrahem
Department of Rheumatology and Rehabilitation, Faculty of Medicine, Cairo University, El-Kasr El-Aini Hospital, Cairo, Egypt,
Mod Rheumatol. 2013 Apr 7. doi: 10.1007/s10165-013-0880-5.
The aim of our study was to determine the prevalence of anti-C1q antibodies and their possible association with clinical presentation in Behcet's disease (BD) patients with special emphasis for patients with vascular involvement. METHODS: Plasma anti-C1q Abs levels were measured using an enzyme-linked immunosorbent assay in 51 BD patients and 25 age- and gender-matched healthy controls. RESULTS: We found elevated concentrations of anti-C1q more frequently in patients with BD (18 %) than in healthy controls (8 %). The highest prevalence was found in patients with vascular BD (42 %) which was significantly higher than patients without vascular BD and healthy controls (p = 0.025). Furthermore, patients with vascular BD had the highest mean anti-C1q levels when compared to BD patients without vascular involvement or healthy control subjects (p = 0.015). We did not find significant differences in the prevalence of any other organ involvement between BD patients with elevated vs. normal anti-C1q ab levels. Anti-C1q ab levels positively correlated with ESR (r = 0.383, p = 0.006) and negatively with C4 (r = -0.304, p = 0.030). CONCLUSION: In conclusion, we found an increased prevalence of anti-C1q autoantibodies in BD patients with vascular involvement. Further large scale longitudinal studies are required to assess and clarify the significance and the pathogenic role of anti-C1q antibodies in BD and other autoimmune diseases in which vasculitis is a component.
我们研究的目的是确定抗C1q抗体的患病率及其与白塞病（BD）患者临床表现的可能关联，特别关注血管受累的患者。方法：采用酶联免疫吸附测定法测量51例BD患者和25例年龄及性别匹配的健康对照者的血浆抗C1q抗体水平。结果：我们发现BD患者中抗C1q浓度升高的频率（18%）高于健康对照者（8%）。血管性BD患者的患病率最高（42%），显著高于无血管性BD的患者和健康对照者（p = 0.025）。此外，与无血管受累的BD患者或健康对照者相比，血管性BD患者的平均抗C1q水平最高（p = 0.015）。我们未发现抗C1q抗体水平升高与正常的BD患者在其他任何器官受累患病率上有显著差异。抗C1q抗体水平与红细胞沉降率呈正相关（r = 0.383，p = 0.006），与C4呈负相关（r = -0.304，p = 0.030）。结论：总之，我们发现血管受累的BD患者中抗C1q自身抗体的患病率增加。需要进一步进行大规模纵向研究，以评估和阐明抗C1q抗体在BD及其他以血管炎为组成部分的自身免疫性疾病中的意义和致病作用。
