Yesilbahar Sok. 68/14 Goztepe 34726 Istanbul Turkey.
Curr Pharm Des. 2014;20(4):529-35. doi: 10.2174/138161282004140213124141.
Epidemiological studies indicate increased mortality rates in cohorts of patients with psoriatic arthritis (PsA). Psoriasis is associated with an enhanced cardiovascular risk. The excess mortality in psoriasis and PsA is predominantly due to coronary artery disease. The aim of this review is to overview the biomarkers and/or mediators of increased cardiovascular risk in patients with psoriasis and PsA. We searched through Medline/PubMed to retrieve sources on cardiovascular disease (CVD), related risk factors and inflammatory markers in psoriasis and PsA. We analyzed the relationship between psoriasis and novel vascular biomarkers with potential use for preventive studies. Studies underline the importance of considering psoriatic patients as a high-risk population in terms of CVD. Novel biomarkers of inflammation, thrombosis, oxidative stress and atherosclerosis can provide risk stratification and strategies for early detection and treatment of CVD in patients with psoriasis. A better understanding of the association between psoriasis and vascular risk can help the clinician to manage the increased morbidity and mortality related to CVD.
流行病学研究表明，患有银屑病关节炎（PsA）的患者群体死亡率升高。银屑病与心血管风险增加相关。银屑病和 PsA 中过度的死亡率主要归因于冠状动脉疾病。本综述的目的是概述银屑病和 PsA 患者心血管风险增加的生物标志物和/或介质。我们通过 Medline/PubMed 搜索了有关心血管疾病（CVD）、相关危险因素和银屑病及 PsA 中炎症标志物的来源。我们分析了银屑病与新型血管生物标志物之间的关系，这些生物标志物具有用于预防研究的潜在用途。研究强调了将银屑病患者视为 CVD 高危人群的重要性。炎症、血栓形成、氧化应激和动脉粥样硬化的新型生物标志物可以提供风险分层以及用于 CVD 患者早期检测和治疗的策略。更好地了解银屑病与血管风险之间的关系可以帮助临床医生管理与 CVD 相关的发病率和死亡率增加。
