基于异氰化物的多组分反应：无催化剂立体选择性构建多环螺吲哚啉。
Isocyanide-based multicomponent reactions: catalyst-free stereoselective construction of polycyclic spiroindolines.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
出版信息
Org Lett. 2013 Apr 19;15(8):1954-7. doi: 10.1021/ol400606c. Epub 2013 Apr 8.
PMID:23565712
Abstract
A novel catalyst-free one-pot tandem reaction for the stereoselective construction of polycyclic spiroindolines was developed. This method offers a straightforward access to structurally diverse polycyclic spiroindoline derivatives in high yields (up to 90%) with excellent levels of diastereoselectivity.
摘要
发展了一种新型无催化剂一锅串联反应，用于立体选择性构建多环螺吲哚啉。该方法能够以高收率（高达 90%）和优异的非对映选择性，直接获得结构多样的多环螺吲哚啉衍生物。
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