Monga G, Mazzucco G, Novara R, Reale L
Department of Biomedical Sciences, University of Torino, Italy.
Ultrastruct Pathol. 1990 May-Jun;14(3):201-9. doi: 10.3109/01913129009076124.
Fifteen kidney allograft specimens from 14 patients with transplant glomerulopathy were investigated by electron microscopy. Intertubular capillaries of all patients showed splitting and multilayering of the basement membranes, a change recalling that observed in the glomerular basement membranes in transplant glomerulopathy. Although the severity of the lesions varied from case to case, it was, to a certain extent, constant in each specimen and correlated well with the severity of the glomerular basement membrane changes in the same patient. The similarity of the two lesions suggests a possible common pathogenetic mechanism. The constant finding of intertubular capillary splitting and multilayering in patients with transplant glomerulopathy leads to the suspicion of this condition when such changes are found in kidney samples in which glomeruli are lacking. Therefore electron microscopy could achieve a specific diagnostic relevance in this field of nephropathology.
对14例患有移植性肾小球病患者的15个同种异体肾移植标本进行了电子显微镜检查。所有患者的肾小管间毛细血管均显示基底膜分裂和多层化，这种变化让人联想到移植性肾小球病中肾小球基底膜的变化。尽管病变的严重程度因病例而异，但在每个标本中在一定程度上是恒定的，并且与同一患者肾小球基底膜变化的严重程度密切相关。这两种病变的相似性提示可能存在共同的发病机制。在移植性肾小球病患者中持续发现肾小管间毛细血管分裂和多层化，当在缺乏肾小球的肾脏样本中发现这种变化时，就会怀疑患有这种疾病。因此，电子显微镜检查在这个肾病学领域可具有特定的诊断意义。
