Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital of Basel, Basel, Switzerland.
J Plast Reconstr Aesthet Surg. 2013 Jul;66(7):912-6. doi: 10.1016/j.bjps.2013.03.008. Epub 2013 Apr 6.
The classical treatment of basal cell carcinoma (BCC) is surgical removal. Recent scientific interest has shifted towards alternative, non-surgical interventions in order to decrease the morbidity associated with surgical excision.
This study aims to evaluate a novel approach that combines surgical excision with perilesional interferon injection in a pilot study.
A total of 23 patients with facial nodular/solid BCC were enrolled and randomised to receive surgical removal with frozen-section control followed by a single perilesional infiltration of either interferon-α or Ringer's lactate. Patients were evaluated for signs of local complications and recurrence after a minimal follow-up of 1 year.
No major complications occurred after infiltration of interferon. One patient required oral antibiotics in the interferon group and two patients showed a small wound dehiscence. At the 1-year follow-up, one patient suffered from a recurrence in the control group. No recurrence was observed in the interferon group. A single perilesional infiltration of interferon-α was safe and did not increase the local complication rate. No recurrence was observed. A larger study is required to analyse the potential of this combination approach in order to minimise the safety margin and thereby decrease the morbidity associated with surgery while improving the cure rate.
本研究旨在评估一种新方法，即在一项初步研究中，将手术切除与瘤周干扰素注射相结合。
共纳入 23 例面部结节/实体基底细胞癌患者，随机分为两组，一组行手术切除及冷冻切片检查，然后瘤周单次注射干扰素-α或林格氏乳酸盐；另一组仅行手术切除及冷冻切片检查。所有患者均随访至少 1 年，评估局部并发症和复发情况。
干扰素注射后无严重并发症。干扰素组 1 例患者需口服抗生素，2 例患者出现小的伤口裂开。在 1 年随访时，对照组 1 例患者复发，干扰素组未见复发。瘤周单次注射干扰素-α是安全的，不会增加局部并发症的发生率。未见复发。需要更大的研究来分析这种联合治疗方法的潜力，以缩小安全范围，从而降低手术相关的发病率，同时提高治愈率。
