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[密闭舱室环境中乙酸乙酯的毒理学评价]

[Toxicological evaluation of ethyl acetate in conditions of sealed cabin atmospheres].

作者信息

Solomin G I, Gorban' G M, Bizin Iu P, Tikhonova G P, Pilipiuk Z I

出版信息

Kosm Biol Aviakosm Med. 1975 Mar-Apr;9(2):40-4.

PMID:235669
Abstract

Ethyl acetate was studied as an atmosphere contaminant in an enclosed environment. A 90-day continuous experiment on 160 white rats and 120 white mice with three concentrations of the compound (43, 10 and 2 mg/m3) was carried out. Ethyl acetate used in the first two concentrations caused functional disturbances in the state of animals and morphological changes in their viscera. Ethyl acetate at a concentration of 2 mg/m3 was ineffective. The data obtained allow recommendations of permissible concentrations of ethyl acetate vapours in an enclosed atmosphere in relation to a different time of man's exposure.

摘要

在封闭环境中对乙酸乙酯作为一种大气污染物进行了研究。对160只白鼠和120只白小鼠进行了为期90天的连续实验,设置了该化合物的三种浓度(43、10和2毫克/立方米)。前两种浓度的乙酸乙酯导致动物状态出现功能紊乱以及内脏出现形态变化。浓度为2毫克/立方米的乙酸乙酯则无效果。所获得的数据可为不同人体暴露时间下封闭大气中乙酸乙酯蒸气的允许浓度提供建议。

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