伊氏链霉菌中放线菌素G基因簇的鉴定与表征
Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus.
作者信息
Wang Xiaoling, Tabudravu Jioji, Rateb Mostafa Ezzat, Annand Krystal Joan, Qin Zhiwei, Jaspars Marcel, Deng Zixin, Yu Yi, Deng Hai
机构信息
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3LZ, Scotland, UK.
出版信息
Mol Biosyst. 2013 Jun;9(6):1286-9. doi: 10.1039/c3mb70081j. Epub 2013 Apr 9.
The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2-3, respectively.
指导伊卡鲁斯链霉菌中放线菌素G生物合成的基因簇已被鉴定和测序。它包含一个放线菌素合成酶I（ACMS I）基因以及ACMS II和III基因的两个拷贝。遗传分析表明，假定的羟基化和氯化活性之间存在独特的协同关系，因为分别需要转录acmG8和acmG9基因才能生物合成放线菌素G2-3。
Zotero 插件