Instituto Universitario de Bio-Orgánica "Antonio González", Av. Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain.
Eur J Med Chem. 2013 May;63:722-30. doi: 10.1016/j.ejmech.2013.03.018. Epub 2013 Mar 18.
A set of twenty one lycorenine derivatives has been prepared from the alkaloid hippeastrine (1). The modifications performed on hippeastrine included some functional group transformations, structural simplification and preparation of dimers. All alkaloids were tested as potential antimalarial agents, being the hippeastrine dimers the most active compounds.
从生物碱石蒜碱（1）中制备了一组 21 种石蒜裂碱衍生物。对石蒜碱进行的修饰包括一些官能团转化、结构简化和二聚体的制备。所有生物碱均被测试为潜在的抗疟药物，其中石蒜裂碱二聚体是最活跃的化合物。
