Corrigan J J, Jeter M A
Department of Pediatrics, University of Arizona Health Sciences Center, Tucson 85724.
Am J Dis Child. 1990 Jul;144(7):825-8. doi: 10.1001/archpedi.1990.02150310093034.
The newborn's fibrinolytic system is not the same as that in the adult. Hypoplasminogenemia with normal (adult) levels of alpha 2-plasmin inhibitor and plasminogen activator inhibitor are characteristic of the newborn's lytic system. This combination suggests that the newborn may have an impaired lytic system that may explain, in part, the thrombotic events that are frequently observed. Histidine-rich glycoprotein (HRG), another fibrinolytic inhibitor, retards fibrinolysis by interfering with plasminogen's binding to fibrin. Levels of HRG have been reported to be reduced in term newborns. This finding has not been studied recently and to our knowledge, there are no reports of HRG levels in premature infants. The purpose of this study was to measure the plasma levels of HRG and plasminogen in three groups of patients: normal adults (n = 48), normal term newborns (n = 43), and normal premature newborns (n = 18). The protein levels were determined by electroimmunoassay. Cross-immunoelectrophoresis was also performed for HRG. Cord blood was employed for obtaining newborn citrated plasma. The newborns had significantly lower plasminogen and HRG levels when compared with those of the adults. Also, the HRG levels of the premature newborns were lower than those of the term newborns. In conclusion, the newborns had lower levels of HRG than adults, with premature newborns having the lowest levels. This may allow for more plasminogen to be available for fibrin binding even though newborns have hypoplasminogenemia.
新生儿的纤溶系统与成人不同。低纤溶酶原血症伴正常（成人）水平的α2 - 纤溶酶抑制剂和纤溶酶原激活物抑制剂是新生儿纤溶系统的特征。这种组合表明新生儿可能存在纤溶系统受损，这在一定程度上可以解释经常观察到的血栓形成事件。富含组氨酸的糖蛋白（HRG）是另一种纤溶抑制剂，它通过干扰纤溶酶原与纤维蛋白的结合来延缓纤维蛋白溶解。据报道，足月儿的HRG水平降低。这一发现最近未被研究，据我们所知，尚无关于早产儿HRG水平的报道。本研究的目的是测量三组患者的血浆HRG和纤溶酶原水平：正常成年人（n = 48）、正常足月儿（n = 43）和正常早产儿（n = 18）。通过电免疫测定法测定蛋白质水平。还对HRG进行了交叉免疫电泳。采用脐血获取新生儿枸橼酸盐血浆。与成年人相比，新生儿的纤溶酶原和HRG水平显著降低。此外，早产儿的HRG水平低于足月儿。总之，新生儿的HRG水平低于成年人，其中早产儿的水平最低。尽管新生儿存在低纤溶酶原血症，但这可能使更多的纤溶酶原可用于与纤维蛋白结合。
