马拉维一名感染人类免疫缺陷病毒的患者发生史蒂文斯-约翰逊综合征导致严重眼部并发症。
Severe eye complications from Stevens-Johnson syndrome in a human immunodeficiency virus-infected patient in Malawi.
机构信息
Department of Ophthalmology, University of Malawi, Blantyre, Malawi.
出版信息
Am J Trop Med Hyg. 2013 Jul;89(1):162-4. doi: 10.4269/ajtmh.12-0761. Epub 2013 Apr 8.
Abstract
Stevens-Johnson syndrome (SJS) is a severe form of erythema multiforme that primarily affects skin and mucous membranes. In Malawi, manifestations of SJS may become more common in human immunodeficiency virus-infected patients receiving nevirapine-based antiretroviral therapy (ART) because the CD4 cell threshold for starting ART has increased from 250 to 350 cells/μL. We describe a patient with severe ocular complications from SJS that developed soon after initiation of nevirapine-based ART and cotrimoxazole preventive treatment, which led to blindness. We draw attention to preventive measures that can potentially reduce permanent ocular damage from SJS.
摘要
史蒂文斯-约翰逊综合征（SJS）是一种严重的多形性红斑，主要影响皮肤和粘膜。在马拉维，接受基于奈韦拉平的抗逆转录病毒治疗（ART）的人类免疫缺陷病毒（HIV）感染者中，SJS 的表现可能更为常见，因为开始 ART 的 CD4 细胞阈值已从 250 增加到 350 个/μL。我们描述了一名患者在开始基于奈韦拉平的 ART 和复方磺胺甲噁唑预防治疗后不久即出现严重的眼并发症，导致失明。我们提请注意可能减少 SJS 引起的永久性眼部损伤的预防措施。
相似文献
1
Severe eye complications from Stevens-Johnson syndrome in a human immunodeficiency virus-infected patient in Malawi.马拉维一名感染人类免疫缺陷病毒的患者发生史蒂文斯-约翰逊综合征导致严重眼部并发症。
Am J Trop Med Hyg. 2013 Jul;89(1):162-4. doi: 10.4269/ajtmh.12-0761. Epub 2013 Apr 8.
2
Ocular manifestations in patients with Stevens-Johnson syndrome in Malawi-review of the literature illustrated by clinical cases.马拉维史蒂文斯-约翰逊综合征患者的眼部表现：文献复习并结合临床病例加以说明。
Graefes Arch Clin Exp Ophthalmol. 2019 Nov;257(11):2343-2348. doi: 10.1007/s00417-019-04421-z. Epub 2019 Jul 27.
3
Stevens-Johnson syndrome in an HIV-infected patient.一名感染HIV患者的史蒂文斯-约翰逊综合征
AIDS Read. 1999 May-Jun;9(3):184-5, 190.
4
The natural history of Stevens Johnson syndrome: patterns of chronic ocular disease and the role of systemic immunosuppressive therapy.史蒂文斯-约翰逊综合征的自然病史：慢性眼部疾病模式及全身免疫抑制治疗的作用。
Br J Ophthalmol. 2007 Aug;91(8):1048-53. doi: 10.1136/bjo.2006.109124. Epub 2007 Feb 21.
5
Stevens-Johnson syndrome and toxic epidermal necrolysis in sub-Saharan Africa: a multicentric study in four countries.撒哈拉以南非洲的史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症：四个国家的多中心研究。
Int J Dermatol. 2013 May;52(5):575-9. doi: 10.1111/j.1365-4632.2012.05743.x. Epub 2013 Jan 20.
6
Non-nucleoside reverse transcriptase inhibitors (NNRTIs)-induced Stevens-Johnson syndrome and gynecomastia in an HIV-infected child: A case report.非核苷类逆转录酶抑制剂（NNRTIs）诱发一名感染人类免疫缺陷病毒（HIV）儿童出现史蒂文斯-约翰逊综合征和男性乳房发育：一例报告
Ann Dermatol Venereol. 2018 Dec;145(12):773-776. doi: 10.1016/j.annder.2018.07.022. Epub 2018 Oct 6.
7
Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: acute ocular manifestations, causes, and management.多形红斑、史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症：急性眼部表现、病因及治疗
Cornea. 2007 Feb;26(2):123-9. doi: 10.1097/ICO.0b013e31802eb264.
8
Analysis of the acute ophthalmic manifestations of the erythema multiforme/Stevens-Johnson syndrome/toxic epidermal necrolysis disease spectrum.多形红斑/史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症疾病谱的急性眼部表现分析
Ophthalmology. 1995 Nov;102(11):1669-76. doi: 10.1016/s0161-6420(95)30811-1.
9
Severe eye complications from toxic epidermal necrolysis following initiation of Nevirapine based HAART regimen in a child with HIV infection: a case from Cameroon.一名感染艾滋病毒的儿童在开始基于奈韦拉平的高效抗逆转录病毒治疗方案后出现中毒性表皮坏死松解症的严重眼部并发症：喀麦隆的一例病例。
BMC Pediatr. 2018 Mar 13;18(1):108. doi: 10.1186/s12887-018-1088-9.
10
Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study.中国患者眼中史蒂文斯-约翰逊综合征与中毒性表皮坏死松解症急性眼部表现的比较：一项15年回顾性研究
BMC Ophthalmol. 2017 May 12;17(1):65. doi: 10.1186/s12886-017-0464-9.
引用本文的文献
1
Ocular manifestations in patients with Stevens-Johnson syndrome in Malawi-review of the literature illustrated by clinical cases.马拉维史蒂文斯-约翰逊综合征患者的眼部表现：文献复习并结合临床病例加以说明。
Graefes Arch Clin Exp Ophthalmol. 2019 Nov;257(11):2343-2348. doi: 10.1007/s00417-019-04421-z. Epub 2019 Jul 27.
2
Factors Contributing to Long-Term Severe Visual Impairment in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症导致长期严重视力损害的因素。
J Ophthalmol. 2017;2017:2087578. doi: 10.1155/2017/2087578. Epub 2017 Mar 26.
本文引用的文献
1
Long-term outcome of cultivated oral mucosal epithelial sheet transplantation in treatment of total limbal stem cell deficiency.培养口腔黏膜上皮细胞片移植治疗完全性角膜缘干细胞缺乏症的长期疗效。
Ophthalmology. 2011 Aug;118(8):1524-30. doi: 10.1016/j.ophtha.2011.01.039. Epub 2011 May 14.
2
Treatment of acute Stevens-Johnson syndrome and toxic epidermal necrolysis using amniotic membrane: a review of 10 consecutive cases.采用羊膜治疗急性 Stevens-Johnson 综合征和中毒性表皮坏死松解症：10 例连续病例回顾。
Ophthalmology. 2011 May;118(5):908-14. doi: 10.1016/j.ophtha.2011.01.046. Epub 2011 Mar 26.
3
4
Ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis.史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的眼部并发症。
Trop Doct. 2010 Jul;40(3):167-8. doi: 10.1258/td.2010.090250.
5
Management of acute Stevens-Johnson syndrome and toxic epidermal necrolysis utilizing amniotic membrane and topical corticosteroids.利用羊膜和局部皮质类固醇治疗急性 Stevens-Johnson 综合征和中毒性表皮坏死松解症。
Am J Ophthalmol. 2010 Feb;149(2):203-213.e2. doi: 10.1016/j.ajo.2009.08.040. Epub 2009 Dec 14.
6
Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset.在疾病发作时采用类固醇脉冲疗法成功治疗史蒂文斯-约翰逊综合征。
Am J Ophthalmol. 2009 Jun;147(6):1004-11, 1011.e1. doi: 10.1016/j.ajo.2008.12.040. Epub 2009 Mar 14.
7
Risk factors for nevirapine-associated rash among HIV-infected patients with low CD4 cell counts in resource-limited settings.资源有限环境下低CD4细胞计数的HIV感染患者中奈韦拉平相关皮疹的危险因素。
Curr HIV Res. 2008 Jan;6(1):65-9. doi: 10.2174/157016208783571946.
8
Severe cutaneous reactions to sulfadoxine-pyrimethamine and trimethoprim-sulfamethoxazole in Blantyre District, Malawi.马拉维布兰太尔地区对周效磺胺-乙胺嘧啶和甲氧苄啶-磺胺甲恶唑的严重皮肤反应
Am J Trop Med Hyg. 2006 May;74(5):738-43.
9
Correlation of corneal complications with eyelid cicatricial pathologies in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis syndrome.史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症患者角膜并发症与眼睑瘢痕性病变的相关性
Ophthalmology. 2005 May;112(5):904-12. doi: 10.1016/j.ophtha.2004.11.035.
10
Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis.药物使用与史蒂文斯-约翰逊综合征或中毒性表皮坏死松解症的风险。
N Engl J Med. 1995 Dec 14;333(24):1600-7. doi: 10.1056/NEJM199512143332404.
Zotero 插件