马拉维一名感染人类免疫缺陷病毒的患者发生史蒂文斯-约翰逊综合征导致严重眼部并发症。
Severe eye complications from Stevens-Johnson syndrome in a human immunodeficiency virus-infected patient in Malawi.
机构信息
Department of Ophthalmology, University of Malawi, Blantyre, Malawi.
出版信息
Am J Trop Med Hyg. 2013 Jul;89(1):162-4. doi: 10.4269/ajtmh.12-0761. Epub 2013 Apr 8.
Abstract
Stevens-Johnson syndrome (SJS) is a severe form of erythema multiforme that primarily affects skin and mucous membranes. In Malawi, manifestations of SJS may become more common in human immunodeficiency virus-infected patients receiving nevirapine-based antiretroviral therapy (ART) because the CD4 cell threshold for starting ART has increased from 250 to 350 cells/μL. We describe a patient with severe ocular complications from SJS that developed soon after initiation of nevirapine-based ART and cotrimoxazole preventive treatment, which led to blindness. We draw attention to preventive measures that can potentially reduce permanent ocular damage from SJS.
摘要
史蒂文斯-约翰逊综合征（SJS）是一种严重的多形性红斑，主要影响皮肤和粘膜。在马拉维，接受基于奈韦拉平的抗逆转录病毒治疗（ART）的人类免疫缺陷病毒（HIV）感染者中，SJS 的表现可能更为常见，因为开始 ART 的 CD4 细胞阈值已从 250 增加到 350 个/μL。我们描述了一名患者在开始基于奈韦拉平的 ART 和复方磺胺甲噁唑预防治疗后不久即出现严重的眼并发症，导致失明。我们提请注意可能减少 SJS 引起的永久性眼部损伤的预防措施。
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