Jiang Yanming, Liang Ge, Wang Liqiang, Jiang Jingjing, Du Gaiping, Huang Yifei
Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
J Int Med Res. 2013 Apr;41(2):317-24. doi: 10.1177/0300060513475570. Epub 2013 Feb 5.
The pathogenesis of age-related macular degeneration (AMD) remains unknown. Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and a target for inhibition therapy in wet AMD. This study investigated the association between the VEGF +936 C/T gene polymorphism and AMD, in a Chinese Han population.
Patients with AMD, and age- and sex-matched controls were enrolled. Restriction fragment length polymorphism was used to analyse the VEGF +936 polymorphism in the promoter and the 3' untranslated region of the gene.
The study included 200 AMD patients and 200 control subjects. There was a significantly higher prevalence of the TT genotype among AMD patients (9.0%) compared with controls (3.5%); the odds ratio for this genotype in AMD patients was 2.73 (95% confidence intervals 1.11, 6.68). There were no significant associations between any genotype and AMD subphenotypic categories (early, geographic atrophy, choroidal neovascularization).
The present study findings suggested that the VEGF +936 TT genotype was associated with AMD among Han Chinese patients.
年龄相关性黄斑变性（AMD）的发病机制尚不清楚。血管内皮生长因子（VEGF）是血管生成的重要调节因子，也是湿性AMD抑制治疗的靶点。本研究在中国汉族人群中调查VEGF +936 C/T基因多态性与AMD之间的关联。
纳入AMD患者以及年龄和性别匹配的对照。采用限制性片段长度多态性分析该基因启动子和3'非翻译区的VEGF +936多态性。
该研究纳入了200例AMD患者和200例对照。与对照组（3.5%）相比，AMD患者中TT基因型的患病率显著更高（9.0%）；AMD患者中该基因型的比值比为2.73（95%置信区间1.11, 6.68）。任何基因型与AMD亚表型类别（早期、地图样萎缩、脉络膜新生血管）之间均无显著关联。
本研究结果提示，在中国汉族患者中，VEGF +936 TT基因型与AMD相关。
