Momoh M A, Muhamed U, Agboke A A, Akpabio E I, Osonwa Uduma Eke
Department of Pharmaceutics University of Nigeria Nsukka, Enugu State.
Asian Pac J Trop Biomed. 2012 Mar;2(3):181-4. doi: 10.1016/S2221-1691(12)60038-0.
To investigate the immunological effect of Vernonia amygdalina (V. amygdalina) leaf extract and immunace(®) on HIV infected patients taking highly active antiretroviral therapy.
Fresh V. amygdalina leaves were collected within Nsukka area in Enugu State. The leaves were rinsed with distilled water. Two handful of cleaned fresh leaves were soaked in 200 mL water and squeezed gently by hand to a mixture. Clients were divided into four groups and each group was given different combination. They took the medication for four weeks. The immune effect was tested against marketed immune booster in some retroviral clients.
The mean absolute CD4 count was increased in the client who took the extract or supplement. And the clients who took both the extract and supplement had a greater increase in the CD4 count. The increased CD4 was significant as compared with the control group (P<0.05). The skin rashes were also improved in the entire groups.
It can be concluded that the aqueous extract of V. amygdalina and immunace or both have immunological effect on HIV infected patients. Therefore, we suggest that the V. amygdalina extract or immunace or both could be used as adjuvant in the management of HIV/AIDS clients.
研究扁桃斑鸠菊叶提取物和免疫宝（®）对接受高效抗逆转录病毒治疗的HIV感染患者的免疫作用。
在埃努古州Nsukka地区采集新鲜的扁桃斑鸠菊叶。叶片用蒸馏水冲洗。两把洗净的新鲜叶片浸泡在200毫升水中，手动轻轻挤压成混合物。将患者分为四组，每组给予不同组合的药物。他们服用药物四周。在一些逆转录病毒患者中针对市售免疫增强剂测试免疫效果。
服用提取物或补充剂的患者平均绝对CD4细胞计数增加。同时服用提取物和补充剂的患者CD4细胞计数增加幅度更大。与对照组相比，CD4细胞计数的增加具有显著性（P<0.05）。所有组的皮疹也有所改善。
可以得出结论，扁桃斑鸠菊水提取物和免疫宝或两者对HIV感染患者具有免疫作用。因此，我们建议扁桃斑鸠菊提取物或免疫宝或两者可作为辅助药物用于管理HIV/AIDS患者。
