Department of Maternal-Fetal Medicine, Intermountain Healthcare and University of Utah School of Medicine, Murray, UT.
Am J Obstet Gynecol. 2013 Jul;209(1):32.e1-6. doi: 10.1016/j.ajog.2013.04.004. Epub 2013 Apr 6.
Recent recommendations called for obstetricians to abandon the terms of "hyperstimulation" and "hypercontractility" in favor of the more rigidly defined term, "tachysystole" (TS). The aim of the current study is to describe incidence of and risk factors for TS, describe fetal heart rate (FHR) changes associated with TS, and investigate maternal and neonatal outcomes associated with TS.
For this retrospective cohort study, we reviewed and analyzed the intrapartum FHR and tocometric characteristics of all patients with a singleton, nonanomalous fetus in term labor in a single hospital system over a 28-month period. Univariate association testing was done using χ(2) and t tests, comparing demographics, pregnancy characteristics, outcomes, and TS events. Multivariable association testing between risk factors and TS events were tested using generalized estimating equations, adjusting for multiple pregnancies during the study period for the same woman.
There were a total of 50,335 deliveries from 48,529 women during the 28-month period. Of these, there were a total of 7567 TS events in 5363 deliveries among 5332 women. Use of oxytocin or misoprostol, an epidural, hypertension, and induction of labor were associated with an increased risk of TS. We found a doubling of TS events with any oxytocin, a dose-response correlation between oxytocin and TS, FHR changes occurring in a quarter of TS events and, finally, that presence of TS increases the chance of composite neonatal morbidity.
TS is associated with specific risk factors and impacts FHR and neonatal morbidity.
最近的建议呼吁产科医生放弃“过度刺激”和“过度收缩”这两个术语,转而使用更严格定义的术语“宫缩过速”(TS)。本研究旨在描述 TS 的发生率和危险因素,描述与 TS 相关的胎儿心率(FHR)变化,并调查与 TS 相关的母体和新生儿结局。
在这项回顾性队列研究中,我们回顾和分析了在单个医院系统中,28 个月期间所有单胎、非畸形胎儿足月分娩的产妇的产时 FHR 和宫缩图特征。使用 χ(2)和 t 检验进行单变量关联检验,比较人口统计学、妊娠特征、结局和 TS 事件。使用广义估计方程对危险因素和 TS 事件之间的多变量关联进行检验,对于研究期间同一妇女的多胎妊娠进行调整。
在 28 个月期间,共有 48529 名妇女分娩了 50335 例,其中共有 5332 名妇女的 5363 例分娩中发生了 7567 例 TS 事件。使用催产素或米索前列醇、硬膜外麻醉、高血压和引产与 TS 风险增加相关。我们发现,任何剂量的催产素都会使 TS 事件增加一倍,催产素和 TS 之间存在剂量反应关系,TS 事件中有四分之一发生 FHR 变化,最后,TS 的存在增加了复合新生儿发病率的机会。
TS 与特定的危险因素相关,影响 FHR 和新生儿发病率。