[PREFERE - 德国前列腺癌研究：围绕2013年1月研究启动的问题与主张]

[PREFERE - the German prostatic cancer study: questions and claims surrounding study initiation in January 2013].

作者信息

Wiegel T, Albers P, Bussar-Maatz R, Gottberg A, Härter M, Kieser M, Kristiansen G, Nettekoven G, Martus P, Schmidberger H, Wellek S, Stöckle M

机构信息

Klinik für Strahlentherapie und Radioonkologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Deutschland.

出版信息

Urologe A. 2013 Apr;52(4):576-9. doi: 10.1007/s00120-013-3186-5.

DOI:10.1007/s00120-013-3186-5

PMID:23571802

Abstract

The PREFERE study is a multicenter randomized study of patients with low or early intermediate risk for prostatic cancer. The four treatment options, radical prostatectomy, percutaneous irradiation therapy, permanent seed implantation and active surveillance recommended by the German S3 guidelines and international guidelines will be tested and compared with respect to effectiveness and potential side effects. Over a period of 4 years a total of 7,600 patients are to be recruited and assigned to 1 of these 4 therapy forms according to personal preference (by possible exclusion of 1 or 2 therapy options) in a 2-4 arm study design by randomization.

摘要

PREFERE研究是一项针对前列腺癌低风险或早期中度风险患者的多中心随机研究。将对德国S3指南和国际指南推荐的四种治疗方案——根治性前列腺切除术、经皮放射治疗、永久性粒子植入和主动监测——在有效性和潜在副作用方面进行测试和比较。在4年的时间里，总共将招募7600名患者，并在2至4组的研究设计中通过随机化根据个人偏好（可能排除1或2种治疗方案）将其分配到这4种治疗方式中的一种。