Wong H C
Department of Ophthalmology, Flinders Medical Centre, Bedford Park, South Australia.
Aust N Z J Ophthalmol. 1990 Feb;18(1):23-5. doi: 10.1111/j.1442-9071.1990.tb00580.x.
Degeneration of intramural pericytes is the first histopathological lesion seen in diabetic retinopathy. Since pericytes from the optic nerve and brain are spared, such degeneration appears to be specific to the retinal circulation. Recent studies have shown that when retinal pericytes and microvascular endothelial cells are co-cultured in vitro, direct contact between the two types of cells leads to the inhibition of proliferation of endothelial cells. Previously it was shown that when pericytes are cultured in the absence of microvascular endothelial cells, the cultured medium conditioned by the pericytes is actively mitogenic for retinal capillary endothelial cells. Furthermore, conditioned medium from human retinal pigment epithelial cells is also mitogenic for retinal capillary endothelial cells and pericytes. On the basis of these results, a new working hypothesis is proposed for the mechanism of action of photocoagulation used in vasoproliferative retinopathies.
壁内周细胞变性是糖尿病视网膜病变中最早出现的组织病理学损伤。由于来自视神经和大脑的周细胞未受影响，这种变性似乎是视网膜循环所特有的。最近的研究表明，当视网膜周细胞和微血管内皮细胞在体外共培养时，这两种细胞之间的直接接触会导致内皮细胞增殖受到抑制。此前有研究表明，当周细胞在无微血管内皮细胞的情况下培养时，周细胞条件培养液对视网膜毛细血管内皮细胞具有活跃的促有丝分裂作用。此外，人视网膜色素上皮细胞的条件培养液对视网膜毛细血管内皮细胞和周细胞也具有促有丝分裂作用。基于这些结果，针对增殖性视网膜病变中光凝作用机制提出了一个新的工作假说。
