大型双胞胎样本中银屑病的遗传性。
Heritability of psoriasis in a large twin sample.
机构信息
Department of Dermato-Allergology, Gentofte Hospital, Hellerup, Denmark.
出版信息
Br J Dermatol. 2013 Aug;169(2):412-6. doi: 10.1111/bjd.12375.
BACKGROUND
Previous twin studies have shown greater concordance rates for psoriasis in MZ than in DZ twins, and heritability estimates between 66% and 90%. This supports a genetic influence on psoriasis, but also highlights the fact that genes are not the only explanation for the disease.
OBJECTIVES
To study the concordance of psoriasis in a population-based twin sample.
METHODS
Data on psoriasis in 10 725 twin pairs, aged 20-71 years, from the Danish Twin Registry was collected via a questionnaire survey. The concordance and heritability of psoriasis were estimated.
RESULTS
In total, 4·1% of the men and 4·2% of the women had a lifetime history of psoriasis. The proband-wise concordance for psoriasis was larger in monozygotic than in dizygotic twins, 0·33 vs. 0·17. Genetic factors explained 68% (60-75%) of the variation in the susceptibility to psoriasis, whereas the rest of the variation was explained by nonshared environmental factors.
CONCLUSION
The results confirm that psoriasis is a complex multifactorial disease controlled by both exogenous and endogenous factors.
背景
先前的双胞胎研究表明，同卵双胞胎中银屑病的一致性比异卵双胞胎更高，遗传率在 66%至 90%之间。这支持了银屑病受遗传影响，但也凸显了一个事实，即基因并非是该疾病的唯一解释。
目的
研究基于人群的双胞胎样本中银屑病的一致性。
方法
通过问卷调查，从丹麦双胞胎登记处收集了年龄在 20-71 岁的 10725 对双胞胎的银屑病数据。估计了银屑病的一致性和遗传性。
结果
共有 4.1%的男性和 4.2%的女性有银屑病的终身病史。在单卵双胞胎中，银屑病的先证者一致性大于异卵双胞胎，为 0.33 比 0.17。遗传因素解释了银屑病易感性变化的 68%（60-75%），而其余变化则由非共享环境因素解释。
结论
研究结果证实，银屑病是一种复杂的多因素疾病，由外源性和内源性因素共同控制。
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