Johnson & Johnson Santé Beauté France, 92787 Issy-les-Moulineaux, France.
Skin Res Technol. 2013 Aug;19(3):291-8. doi: 10.1111/srt.12040. Epub 2013 Apr 11.
The overall appearance of an aged skin is characterized by a combination of several attributes such as wrinkles, brown spots and sagging. Our objective was to develop and validate a statistical framework to assess the overall anti-ageing benefits of products/procedures.
Different skin attributes were evaluated by a clinical grader and combined using a Principal Component Analysis (PCA). The Skin Ageing Index was defined as the normalized projection of the clinical grading values on the first PCA axis. Several Skin Indexes were built by grouping specific parameters related to a skin condition such as overall ageing, wrinkles and sagging. The method was validated following two steps. Firstly, a clinical study was performed on 173 Caucasian women and the correlation between the Skin Indexes and the volunteers' real and perceived age was estimated. Secondly, a double-blinded placebo-controlled randomized study was performed on 87 Caucasian women to assess the efficacy of an anti-wrinkle cream containing retinol, hyaluronic acid and dihydroxymethylchromone. Facial wrinkles were clinically evaluated and a Wrinkle Index was built.
All indexes were highly correlated with the real and the perceived age (0.57 ≤ Pearson R ≤ 0.92, P-value ≤ 0.05). Finally, the Wrinkle Index provides documented evidence that the tested product significantly reduced the appearance of wrinkles versus the placebo and the baseline assessment (-23.53% after 4 weeks, -27.83% after 8 weeks).
Skin ageing Indexes capture information relevant to the visual transformation of facial skin with age, while providing documented product benefits. These tools may enable a simpler and more consistent comparison of anti-ageing products/procedures.
老化皮肤的整体外观表现为多种特征的综合，如皱纹、褐斑和松弛。我们的目的是开发和验证一种统计框架，以评估产品/程序的整体抗衰老功效。
临床评分员评估不同的皮肤特征，并使用主成分分析（PCA）进行组合。皮肤老化指数定义为临床评分值在第一 PCA 轴上的归一化投影。通过将与皮肤状况相关的特定参数（如整体老化、皱纹和松弛）分组，构建了几种皮肤指数。该方法通过两步进行验证。首先，在 173 名白种女性中进行了一项临床研究，估计了皮肤指数与志愿者真实年龄和感知年龄之间的相关性。其次，对 87 名白种女性进行了一项双盲安慰剂对照随机研究，以评估含有视黄醇、透明质酸和二羟甲基色酮的抗皱霜的功效。对面部皱纹进行临床评估，并构建了皱纹指数。
所有指数均与真实年龄和感知年龄高度相关（0.57≤Pearson R≤0.92，P 值≤0.05）。最后，皱纹指数提供了有文件证明的证据，表明测试产品与安慰剂和基线评估相比，显著减少了皱纹的外观（4 周后减少 23.53%，8 周后减少 27.83%）。
皮肤老化指数可捕捉与面部皮肤随年龄变化的视觉变化相关的信息，同时提供有文件证明的产品功效。这些工具可以实现更简单、更一致的抗衰老产品/程序比较。
