Billard J M
Laboratoire de Physiologie de la Motricité, URA 385, Paris, France.
Brain Res. 1990 Apr 23;514(1):155-8. doi: 10.1016/0006-8993(90)90450-p.
The sensitivity of neurons of the deep cerebellar nuclei to iontophoretic application of taurine (TAU) and gamma-aminobutyric acid (GABA) has been studied in vivo in rats. Both TAU and GABA produced a dose-dependent depression of the firing rate. Both the inhibitory actions of TAU and GABA were antagonized by bicuculline (BIC) and picrotoxin (PIC) but not by strychnine (STRY) meaning that TAU had a 'GABA-like' effect in the deep cerebellar nuclei. Simultaneous application of TAU and GABA induced not an additive but a synergistic inhibitory effect on the discharge of the neurons of the interposed and dentate nuclei. These results indicate the involvement of TAU in the inhibitory processes acting on neurons of the deep cerebellar nuclei.
在大鼠体内研究了小脑深部核团神经元对离子电渗法施加牛磺酸（TAU）和γ-氨基丁酸（GABA）的敏感性。TAU和GABA均产生剂量依赖性的放电频率抑制。TAU和GABA的抑制作用均被荷包牡丹碱（BIC）和印防己毒素（PIC）拮抗，但不被士的宁（STRY）拮抗，这意味着TAU在小脑深部核团具有“GABA样”作用。同时施加TAU和GABA对中间核和齿状核神经元的放电产生的不是相加而是协同抑制作用。这些结果表明TAU参与了作用于小脑深部核团神经元的抑制过程。
