Retinal X-afferents bifurcate to lateral geniculate X-cells and to the pretectum or superior colliculus in cats.

The question of whether retinal X-type ganglion cell axons project via axonal bifurcation to both the dorsal lateral geniculate nucleus (LGN) and the pretectum (PT) or the superior colliculus (SC) in the cat, was studied by examining the effects of PT and/or SC stimulation on the LGN cells. X-cells that responded monosynaptically to PT or SC stimulation were encountered as follows: 29%, 26%, and 4% of the tested X-cells responded to stimulation of PT, SC, and both, respectively. For the X-cells activated from the PT or SC, the latency tended to be a little longer than optic chiasm latency. The receptive field centers of the X-cells were located within the receptive fields of the multiple units from the SC whose stimulation could activate the corresponding X-cells. The present results demonstrate that a substantial proportion of the X-type LGN cells receive excitatory inputs from the retinal X-type ganglion cell axons that branch to the PT or the SC.