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Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry.人源 CYP17 中的氢键差异决定了羟化作用与裂合作用的化学性质。
Angew Chem Int Ed Engl. 2013 May 10;52(20):5342-5. doi: 10.1002/anie.201300760. Epub 2013 Apr 10.
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Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone.人细胞色素 CYP17A1：与 17-羟孕酮的裂解酶活性受损的结构基础。
J Am Chem Soc. 2018 Jun 13;140(23):7324-7331. doi: 10.1021/jacs.8b03901. Epub 2018 Jun 5.
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Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202.人类细胞色素P450 CYP17A1：天冬酰胺202对底物偏好性的调控
Biochemistry. 2018 Feb 6;57(5):764-771. doi: 10.1021/acs.biochem.7b01067. Epub 2018 Jan 24.
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Unveiling the crucial intermediates in androgen production.揭示雄激素生成过程中的关键中间体。
Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15856-61. doi: 10.1073/pnas.1519376113. Epub 2015 Dec 14.
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Cryoradiolysis of oxygenated cytochrome P450 17A1 with lyase substrates generates expected products.氧合细胞色素 P450 17A1 的冷冻放射解作用与裂合底物生成预期产物。
J Inorg Biochem. 2024 Aug;257:112582. doi: 10.1016/j.jinorgbio.2024.112582. Epub 2024 May 4.
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Molecular dynamics of substrate complexes with hamster cytochrome P450c17 (CYP17): mechanistic approach to understanding substrate binding and activities.仓鼠细胞色素P450c17（CYP17）底物复合物的分子动力学：理解底物结合与活性的机制方法
Biochim Biophys Acta. 2003 Feb 17;1619(3):291-300. doi: 10.1016/s0304-4165(02)00488-9.
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Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.人细胞色素P450 17A1将孕酮和孕烯醇酮两步氧化为雄激素的动力学持续性。
J Biol Chem. 2017 Aug 11;292(32):13168-13185. doi: 10.1074/jbc.M117.794917. Epub 2017 Jul 6.
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Developmental changes of serum steroids produced by cytochrome P450c17 in rat.大鼠细胞色素P450c17产生的血清类固醇的发育变化。
Steroids. 2006 Feb;71(2):165-70. doi: 10.1016/j.steroids.2005.09.006. Epub 2005 Nov 8.
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Structures of human steroidogenic cytochrome P450 17A1 with substrates.人甾体生成细胞色素P450 17A1与底物的结构。
J Biol Chem. 2014 Nov 21;289(47):32952-64. doi: 10.1074/jbc.M114.610998. Epub 2014 Oct 9.
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Conformational selection dominates binding of steroids to human cytochrome P450 17A1.构象选择主导甾体化合物与人细胞色素 P45017A1 的结合。
J Biol Chem. 2019 Jun 28;294(26):10028-10041. doi: 10.1074/jbc.RA119.008860. Epub 2019 May 9.
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Cytochrome P450 and P450 11A1 retain Compound I (FeO) chemistry with electrophilic substrates poised for Compound 0 (FeO) reactions.细胞色素P450和P450 11A1保留了化合物I（FeO）的化学性质，其中亲电底物为化合物0（FeO）反应做好了准备。
J Biol Chem. 2025 Jul;301(7):110378. doi: 10.1016/j.jbc.2025.110378. Epub 2025 Jun 14.
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Reactivity of a heterobinuclear heme-peroxo-Cu complex with -substituted catechols shows a p -dependent change in mechanism.一种异双核血红素-过氧-铜配合物与对位取代儿茶酚的反应性显示出反应机理随p的依赖性变化。
Chem Sci. 2024 Dec 30;16(5):2402-2412. doi: 10.1039/d4sc05623j. eCollection 2025 Jan 29.
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Optical annealing of peroxo-ferric intermediates in CYP17A1 and product formation.光退火在 CYP17A1 中过氧铁中间体和产物形成中的应用。
J Inorg Biochem. 2024 Nov;260:112701. doi: 10.1016/j.jinorgbio.2024.112701. Epub 2024 Aug 17.
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Cryoradiolysis of oxygenated cytochrome P450 17A1 with lyase substrates generates expected products.氧合细胞色素 P450 17A1 的冷冻放射解作用与裂合底物生成预期产物。
J Inorg Biochem. 2024 Aug;257:112582. doi: 10.1016/j.jinorgbio.2024.112582. Epub 2024 May 4.
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Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-Demethylation.氧-18 标记揭示细胞色素 P450 51 甾醇 14α-脱甲基化最后一步中的混合 Fe-O 机制。
Angew Chem Int Ed Engl. 2024 Feb 26;63(9):e202317711. doi: 10.1002/anie.202317711. Epub 2024 Jan 24.
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Biotransformation of Δ-Progesterone Using Selected Entomopathogenic Filamentous Fungi and Prediction of Its Products' Bioactivity.Δ-孕烯醇酮的生物转化利用选择的昆虫病原丝状真菌及其产物生物活性的预测。
Int J Mol Sci. 2023 Dec 29;25(1):508. doi: 10.3390/ijms25010508.
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Steroid 17α-hydroxylase/17, 20-lyase (cytochrome P450 17A1).甾体 17α-羟化酶/17,20-裂合酶（细胞色素 P45017A1）。
Methods Enzymol. 2023;689:39-63. doi: 10.1016/bs.mie.2023.04.001. Epub 2023 Apr 25.
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Diverse reactions catalyzed by cytochrome P450 and biosynthesis of steroid hormone.细胞色素P450催化的多种反应与甾体激素的生物合成。
Biophys Physicobiol. 2022 Jun 1;19:e190021. doi: 10.2142/biophysico.bppb-v19.0021. eCollection 2022.
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Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human CYP17A1.天门冬氨酸 202 对人 CYP17A1 活性部位结构和底物偏好性的影响
Biochemistry. 2022 Apr 5;61(7):583-594. doi: 10.1021/acs.biochem.2c00023. Epub 2022 Mar 15.
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Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1.人 P450 CYP17A1 中临床相关 E305G 突变的作用机制。
Biochemistry. 2021 Nov 2;60(43):3262-3271. doi: 10.1021/acs.biochem.1c00282. Epub 2021 Oct 18.
本文引用的文献
1
CO, NO and O as Vibrational Probes of Heme Protein Interactions.一氧化碳、一氧化氮和氧作为血红素蛋白相互作用的振动探针。
Coord Chem Rev. 2013 Jan 15;257(2):511-527. doi: 10.1016/j.ccr.2012.05.008. Epub 2012 Jun 6.
2
Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.细胞色素 P450 17A1 与前列腺癌药物阿比特龙和 TOK-001 的结构。
Nature. 2012 Jan 22;482(7383):116-9. doi: 10.1038/nature10743.
3
Defining CYP3A4 structural responses to substrate binding. Raman spectroscopic studies of a nanodisc-incorporated mammalian cytochrome P450.定义 CYP3A4 对底物结合的结构响应。纳米盘包埋的哺乳动物细胞色素 P450 的拉曼光谱研究。
J Am Chem Soc. 2011 Feb 9;133(5):1357-66. doi: 10.1021/ja105869p. Epub 2011 Jan 5.
4
A review of mechanistic studies on aromatase (CYP19) and 17α-hydroxylase-17,20-lyase (CYP17).芳香化酶（CYP19）和 17α-羟化酶-17,20-裂合酶（CYP17）的机制研究综述。
J Steroid Biochem Mol Biol. 2011 May;125(1-2):2-12. doi: 10.1016/j.jsbmb.2010.11.003. Epub 2010 Nov 19.
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The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.人类类固醇生成及其疾病的分子生物学、生物化学和生理学。
Endocr Rev. 2011 Feb;32(1):81-151. doi: 10.1210/er.2010-0013. Epub 2010 Nov 4.
6
Cytochromes P450 in nanodiscs.纳米盘中的细胞色素P450
Biochim Biophys Acta. 2011 Jan;1814(1):223-9. doi: 10.1016/j.bbapap.2010.05.017. Epub 2010 Jun 8.
7
At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17.在类固醇激素生物合成的十字路口：CYP17的作用、底物特异性及进化发展
Biochim Biophys Acta. 2011 Jan;1814(1):200-9. doi: 10.1016/j.bbapap.2010.06.021. Epub 2010 Jul 7.
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Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscs.第11章 - 膜蛋白在磷脂双层纳米盘中的重构。
Methods Enzymol. 2009;464:211-31. doi: 10.1016/S0076-6879(09)64011-8.
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Membrane protein assembly into Nanodiscs.膜蛋白组装成纳米盘。
FEBS Lett. 2010 May 3;584(9):1721-7. doi: 10.1016/j.febslet.2009.10.024. Epub 2009 Oct 16.
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Resonance Raman characterization of the peroxo and hydroperoxo intermediates in cytochrome P450.细胞色素P450中过氧和氢过氧中间体的共振拉曼光谱表征
J Phys Chem A. 2008 Dec 18;112(50):13172-9. doi: 10.1021/jp8017875.
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