Lawler S D, Khokhar M T, Davies H, Williams G J, Powles R
Leukaemia Unit, Royal Marsden Hospital, Sutton, Surrey, England.
Cancer Genet Cytogenet. 1990 Jul 15;47(2):249-63. doi: 10.1016/0165-4608(90)90034-8.
Cytogenetic studies were made in 20 leukemic patients who relapsed after treatment by allogeneic bone marrow transplantation (BMT). Seven of the eight patients in whom no chromosomal abnormalities were detected in leukemic cells before BMT developed clonal abnormalities after BMT, and in two of these patients two independent clones were observed. Most patients in whom clones were detected before BMT showed evidence of clonal evolution after BMT. Nonclonal abnormalities were also observed in clonal cells. These additional abnormalities, both clonal and nonclonal, were attributed to the effects of total body irradiation received by the patient before BMT. There was no evidence of recurrence of leukemia in donor cells among these patients. We concluded that the cells found in leukemic recurrence were derived from the original leukemic clone.
对20例接受异基因骨髓移植（BMT）治疗后复发的白血病患者进行了细胞遗传学研究。在BMT前白血病细胞中未检测到染色体异常的8例患者中，有7例在BMT后出现了克隆性异常，其中2例患者观察到两个独立的克隆。大多数在BMT前检测到克隆的患者在BMT后显示出克隆进化的证据。在克隆细胞中也观察到非克隆性异常。这些额外的异常，包括克隆性和非克隆性异常，归因于患者在BMT前接受的全身照射的影响。在这些患者中没有供体细胞白血病复发的证据。我们得出结论，白血病复发时发现的细胞源自原始白血病克隆。
