Chen S S, Li Q
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.
Cell Immunol. 1990 Jul;128(2):353-61. doi: 10.1016/0008-8749(90)90032-m.
Porcine transforming growth factor-beta 1 (TGF-beta 1) exerts a unique bifunctional immunoregulatory effect on IgA responses in murine mesenteric and Peyer's patches lymphocyte cultures. TGF-beta 1 is a potent costimulator of LPS-induced IgA responses. The enhancement was observed at TGF-beta 1 at 0.1 to 10 ng/ml in both early and late phases of IgA responses from Day 5 to Day 14 in cultures. On the contrary, TGF-beta 1 exerts a profound immunosuppressive effect on IL-5-induced IgA synthesis. TGF-beta 1 is a natural cytokine produced by intestinal epithelial cells and may account for the polyclonal production and secretion of IgA at the mucosal surface and ensure the integrity of the primary host defense by mucosa-associated lymphoid tissues (MALT).
猪转化生长因子-β1（TGF-β1）对鼠肠系膜和派尔集合淋巴结淋巴细胞培养中的IgA反应具有独特的双功能免疫调节作用。TGF-β1是脂多糖诱导的IgA反应的有效共刺激因子。在培养物中，从第5天到第14天的IgA反应的早期和晚期阶段，均观察到0.1至10 ng/ml的TGF-β1有增强作用。相反，TGF-β1对白细胞介素-5诱导的IgA合成具有显著的免疫抑制作用。TGF-β1是肠道上皮细胞产生的一种天然细胞因子，可能解释了黏膜表面IgA的多克隆产生和分泌，并通过黏膜相关淋巴组织（MALT）确保宿主初级防御的完整性。
