男性慢性肾衰竭患者唾液β2-微球蛋白与尿毒症强度的关系。

The Relationship between Salivary Beta-2 Microglobulin and Uremia Intensity in Men with Chronic Renal Failure.

机构信息

1. Department of Oral Medicine, Dental Research Center, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.

出版信息

Cell J. 2013 Winter;14(4):276-81. Epub 2013 Feb 20.

PMID:23577307

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3593932/

Abstract

OBJECTIVE

This study defines the relationship between salivary beta-2 microglobulin (β2-M) and intensity of uremia in male patients diagnosed with chronic renal failure (CRF).

MATERIALS AND METHODS

In total of 42 males were enrolled in a case-control study. There were 21 cases of CRF and 21 control cases. We collected 10cc of saliva plus 5 cc of blood from all patients to determine β2-M, blood urea nitrogen (BUN) and creatinine (Cr) levels.

RESULTS

There was a correlation between the level of serum BUN and salivary urea in controls and patients, which was statistically significant for controls (p=0.028).The correlation between serum and salivary Cr was 0.195 in controls (p=0.398) and 0.598 in patients (p=0.006), which was statistically significant in patients. The correlation between serum and saliva was 0.133 (p=0.566) in controls and 0.078 (p=0.737) in patients, which was not statistically significant. The correlation between serum BUN and β2-M was 0.168 (p=0.469) in the control group and 0.629 (p=0.002) in patients, which was statistically significant in patients. The correlation between serum Cr and β2-M was 0.110 (p=0.635) in the control group and 0.678 (p=0.001) in patients, which was statistically significant in patients. The correlation between serum BUN and salivary β2-M was 0.093 (p=0.0690) in controls and 0.152 (p=0.152) in patients, which was not statistically significant. The correlation between serum Cr and salivary β2-M was 0.072 (p=0.070) in the control group and 0.286 (p=0.209) in patients, which was not statistically significant in either group.

CONCLUSION

The results of the study indicated that salivary β2-M cannot be used as a noninvasive indicator to detect the severity of renal failure.

摘要

目的

本研究旨在定义唾液β2-微球蛋白（β2-M）与男性慢性肾衰竭（CRF）患者尿毒症强度之间的关系。

材料与方法

共纳入 42 名男性患者进行病例对照研究。其中 21 例为 CRF 患者，21 例为对照组。我们从所有患者中收集 10cc 唾液和 5cc 血液，以确定β2-M、血尿素氮（BUN）和肌酐（Cr）水平。

结果

对照组和患者的血清 BUN 水平与唾液尿素之间存在相关性，对照组具有统计学意义（p=0.028）。对照组血清与唾液 Cr 的相关性为 0.195（p=0.398），患者组为 0.598（p=0.006），患者组具有统计学意义。对照组血清与唾液的相关性为 0.133（p=0.566），患者组为 0.078（p=0.737），无统计学意义。对照组血清 BUN 与β2-M 的相关性为 0.168（p=0.469），患者组为 0.629（p=0.002），患者组具有统计学意义。对照组血清 Cr 与β2-M 的相关性为 0.110（p=0.635），患者组为 0.678（p=0.001），患者组具有统计学意义。对照组血清 BUN 与唾液β2-M 的相关性为 0.093（p=0.0690），患者组为 0.152（p=0.152），无统计学意义。对照组血清 Cr 与唾液β2-M 的相关性为 0.072（p=0.070），患者组为 0.286（p=0.209），两组均无统计学意义。