Nutescu Edith A
University of Illinois at Chicago, College of Pharmacy & Medical Center, 833 South Wood St., MC 886, Rm. 164, Chicago, IL 60612, USA.
J Manag Care Pharm. 2006 Oct;12(8 Suppl):S17-21.
To quantify the economic burden of chronic stable angina in the United States, characterize recent trends in the use of coronary revascularization, and compare the clinical outcomes and long-term costs of percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), and medical management in patients with stable angina.
The direct and indirect costs of stable angina are measured in tens of billions of dollars in the United States, with hospitalization contributing a large amount to the costs. The use of coronary revascularization, particularly PCI and insertion of coronary stents, has increased dramatically in recent years. The long-term costs of PCI and CABG are similar and high. Revascularization is sometimes used without an adequate trial of medical management, despite higher costs and a lack of evidence of long-term clinical benefits from revascularization.
Chronic stable angina is a costly condition. Medical management should be used before considering costly revascularization, unless medical management is contraindicated.
量化美国慢性稳定型心绞痛的经济负担,描述冠状动脉血运重建使用情况的近期趋势,并比较经皮冠状动脉介入治疗(PCI)、冠状动脉旁路移植术(CABG)和药物治疗对稳定型心绞痛患者的临床结局及长期成本。
在美国,稳定型心绞痛的直接和间接成本达数百亿美元,住院费用占成本的很大一部分。近年来,冠状动脉血运重建的使用,尤其是PCI和冠状动脉支架置入术,显著增加。PCI和CABG的长期成本相似且高昂。尽管血运重建成本更高且缺乏长期临床获益的证据,但有时在未充分试用药物治疗的情况下就使用血运重建。
慢性稳定型心绞痛是一种代价高昂的疾病。除非有药物治疗禁忌,否则在考虑进行代价高昂的血运重建之前应先采用药物治疗。