Effects of iproveratril on isolated heart mitochondria.

The effects of iproveratril on oxygen uptake and oxidative phosphorylation of succinate, glutamate and alfa-ketoglutarate were studied. Oxidative phosphorylation and oxidation of NAD+-linked substrated by heart mitochondria were depressed by 1.15 times 10-3M iproveratril. The activity of NADH-oxidase, NADH-cytochrome c reductase and heart mitochondrial transporting particles were depressed by iproveratril. When succinate was the substrate oxidative phosphorylation was depressed but oxygen uptake was stimulated about 370%. Swelling induced by iproveratril was analysed by electron microscopy.