Graham R A, Siddik Z H, Hohn D C
Department of General Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Cancer Chemother Pharmacol. 1990;26(3):210-4. doi: 10.1007/BF02897201.
Cisplatin (3 mg/kg) was infused through the hepatic artery in nine mongrel dogs. Four of these dogs underwent simultaneous extracorporeal hemofiltration (ECH) of the hepatic venous effluent using a high-flow, dual-lumen catheter placed in the vena cava at the level of the hepatic veins. Platinum levels were measured in the plasma, urine, and ultrafiltrate and in kidney and liver tissue. ECH significantly reduced systemic drug exposure as measured by the AUC for free and total platinum, by urinary excretion, and by 24-h kidney levels. Regional liver levels were minimally affected. Recovery of platinum in the ultrafiltrate was 40% +/- 14%. ECH resulted in efficient extraction of platinum and reduced systemic drug exposure with relative preservation of regional hepatic drug exposure.
对9只杂种犬经肝动脉输注顺铂（3毫克/千克）。其中4只犬同时使用置于肝静脉水平下腔静脉的高流量双腔导管对肝静脉流出液进行体外血液滤过（ECH）。测定血浆、尿液、超滤液以及肾脏和肝脏组织中的铂水平。通过游离铂和总铂的AUC、尿排泄量以及24小时肾脏水平测定，ECH显著降低了全身药物暴露。局部肝脏水平受影响最小。超滤液中铂的回收率为40%±14%。ECH可有效提取铂并减少全身药物暴露，同时相对保留局部肝脏药物暴露。
