Venho V M, Aukee S, Jussila J, Mattila M J
Scand J Gastroenterol. 1975;10(1):43-7.
The effect of gastric surgery on the absorption of quinidine, ethambutol, and sulphafurazole was studied in 14 male patients, all serving as their own controls. Antrectomy with gastroduodenostomy (ABI) and selective vagotomy lowered the serum levels of all drugs significantly during the 6-hour test period. Excretion of drugs in 6-hour urine also decreased. Three patients showed practically no absorption up to 2 hours, and even therafter the absorption was lowered. Over one year after operation the urinary excretion of ethambutol, but not of the other drugs, was improved. ABI alone did not modify absorption. Preoperative gastric retention seemed to delay absorption.
对14名男性患者进行了胃手术对奎尼丁、乙胺丁醇和磺胺异恶唑吸收影响的研究，所有患者均以自身作为对照。胃十二指肠吻合术（ABI）胃切除术和选择性迷走神经切断术在6小时测试期内显著降低了所有药物的血清水平。6小时尿液中的药物排泄量也减少了。3名患者在2小时内几乎没有吸收，甚至在此之后吸收也降低了。术后一年多，乙胺丁醇的尿排泄量有所改善，但其他药物没有。单独的ABI并没有改变吸收。术前胃潴留似乎会延迟吸收。
