Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J Am Soc Nephrol. 2013 May;24(6):873-6. doi: 10.1681/ASN.2012090931. Epub 2013 Apr 11.
For decades we have known that reciprocal inductive interactions between the embryonic ureteric bud and the metanephric mesenchyme are the basis for kidney development. Signals from the mesenchyme promote the branching of the bud, whereas signals from the bud regulate the survival, proliferation, and differentiation of nephron progenitors. Due to the complex nature of the bud-derived signals, progress in identifying these factors has been slow. However, in the last several years, tremendous advances have been made in identifying specific roles for various secreted proteins in nephron progenitor cell development. Here, we briefly review the roles for Fgfs and Wnts in induction of the nephron progenitors.
几十年来，我们已经知道，胚胎输尿管芽和后肾间充质之间的相互诱导相互作用是肾脏发育的基础。间充质的信号促进芽的分支，而芽的信号调节肾祖细胞的存活、增殖和分化。由于芽衍生信号的复杂性，鉴定这些因子的进展一直很缓慢。然而，在过去的几年中，在鉴定各种分泌蛋白在肾祖细胞发育中的特定作用方面取得了巨大进展。在这里，我们简要回顾了 Fgfs 和 Wnts 在诱导肾祖细胞中的作用。
