From the *Departments of Medicine, †Emergency Medicine, ‡Surgery, §Radiology and ¶Nuclear Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi; ∥Department of Life Science, National Chung Cheng University, Chia-Yi, Taiwan;**College of Health Sciences, Chang Jung Christian University, Tainan; ††Center of General Education, Chia Nan University of Pharmacy & Science, Tainan; and ‡‡Medical Center and School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Clin Nucl Med. 2013 Dec;38(12):e465-6. doi: 10.1097/RLU.0b013e3182867581.
A 44-year-old woman suffered from epigastralgia for 1 month. An abdominal sonography revealed a space-occupying lesion, about 6 cm, in the spleen. Contrast-enhanced CT revealed enhanced splenic lesions. The PET/CT showed FDG-avid multiple splenic nodules with a "prunes on bread" appearance in the maximum-intensity-projection image (MIP image). In sectional PET/CT images, a central cold area with peripheral increased FDG uptake in the splenic nodule is visible. Because splenic malignancy was suspected, laparoscopic splenectomy was performed. Histology revealed multiple nodules with angiomatoid appearance, CD31(+), CD34(+) and HHV-8(-) in the vascular space, typical for the rare sclerosing angiomatoid nodular transformation (SANT).
一位 44 岁女性因上腹痛 1 个月就诊。腹部超声显示脾脏内有占位性病变，约 6cm。增强 CT 显示脾脏病变强化。PET/CT 显示 FDG 摄取的多发脾脏结节，在最大密度投影图像（MIP 图像）上呈“葡萄干面包”外观。在断层 PET/CT 图像上，脾脏结节内可见中央冷区和周围 FDG 摄取增加。由于怀疑脾脏恶性肿瘤，行腹腔镜脾切除术。组织学显示多个结节呈血管瘤样外观，血管腔中 CD31（+）、CD34（+）和 HHV-8（-），符合罕见的硬化性血管母细胞瘤样结节转化（SANT）。
