中枢神经系统原发性黑色素瘤的模型涉及 NRAS。

A model for primary melanoma of the CNS implicates NRAS.

机构信息

Stem Cell Program and Division of Hematology/Oncology, Children's Hospital, and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Cancer Discov. 2013 Apr;3(4):382-3. doi: 10.1158/2159-8290.CD-13-0076.

DOI:10.1158/2159-8290.CD-13-0076

PMID:23580282

Abstract

In this issue of Cancer Discovery, Pedersen and colleagues present the first mouse model of primary CNS melanoma, which arises when oncogenic NRAS is expressed from the endogenous Nras promoter in melanocytes during embryogenesis. In support of this model, two pediatric cases of NRAS-mutant primary melanoma of the CNS are identified.

摘要

在本期《Cancer Discovery》中，Pedersen 及其同事展示了首个原发性中枢神经系统黑色素瘤的小鼠模型，该模型是在胚胎发生过程中，致瘤性 NRAS 从黑素细胞中的内源性 Nras 启动子表达时出现的。该模型得到了两项支持：鉴定出了两例儿童 CNS 中 NRAS 突变型原发性黑色素瘤病例。