了解具有种系 Apc 突变的啮齿动物模型中的表型变异。
Understanding phenotypic variation in rodent models with germline Apc mutations.
机构信息
Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA.
出版信息
Cancer Res. 2013 Apr 15;73(8):2389-99. doi: 10.1158/0008-5472.CAN-12-4607. Epub 2013 Apr 11.
Abstract
Adenomatous polyposis coli (APC) is best known for its crucial role in colorectal cancer suppression. Rodent models with various Apc mutations have enabled experimental validation of different Apc functions in tumors and normal tissues. Since the development of the first mouse model with a germline Apc mutation in the early 1990s, 20 other Apc mouse and rat models have been generated. This article compares and contrasts currently available Apc rodent models with particular emphasis on providing potential explanations for their reported variation in three areas: (i) intestinal polyp multiplicity, (ii) intestinal polyp distribution, and (iii) extraintestinal phenotypes.
摘要
腺瘤性结肠息肉病（APC）最广为人知的作用是抑制结直肠癌。具有各种 APC 突变的啮齿动物模型使不同 APC 功能在肿瘤和正常组织中的实验验证成为可能。自 20 世纪 90 年代初开发出第一个具有种系 APC 突变的小鼠模型以来，已经产生了 20 种其他 APC 小鼠和大鼠模型。本文比较和对比了目前可用的 APC 啮齿动物模型，特别强调了对三个方面报告的变异性的潜在解释：（i）肠息肉多发性，（ii）肠息肉分布，和（iii）肠外表型。
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