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杀虫剂混合物诱导大鼠睾丸氧化应激和生化紊乱。

Oxidative stress and biochemical perturbations induced by insecticides mixture in rat testes.

机构信息

Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Egypt.

出版信息

J Environ Sci Health B. 2013;48(7):593-9. doi: 10.1080/03601234.2013.774998.

Abstract

The joint action of pyrethroids, lambda-cyhalothrin (LC) in combination with organophosphates, fenitrothione (FNT) on antioxidant defense system and lipid peroxidation biomarkers in rat testes was studied. The results suggest that incubation of testes homogenate with different concentrations of insecticide mixture for different time intervals significantly decreased the activity of antioxidant enzymes, like glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT), and the level of reduced glutathione (GSH). In addition, a significant inhibition in transaminases (AST, ALT), phosphatases (AcP, AlP) activity and protein content were observed. On the other hand, FNT plus LC increased the cellular lipid peroxidation (LPO) level and the activity of lactate dehydrogenase (LDH). In conclusion, the use of insecticides mixture might cause marked oxidative damage in a concentration and time-dependent manner.

摘要

拟除虫菊酯、氯氰菊酯(LC)与有机磷、杀螟松(FNT)联合作用对大鼠睾丸抗氧化防御系统和脂质过氧化生物标志物的影响。结果表明,不同浓度的杀虫剂混合物在不同时间间隔孵育睾丸匀浆,显著降低了谷胱甘肽 S-转移酶(GST)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)等抗氧化酶的活性以及还原型谷胱甘肽(GSH)的水平。此外,还观察到转氨酶(AST、ALT)、磷酸酶(AcP、AlP)活性和蛋白质含量的显著抑制。另一方面,FNT 加 LC 增加了细胞脂质过氧化(LPO)水平和乳酸脱氢酶(LDH)的活性。总之,杀虫剂混合物的使用可能会导致明显的氧化损伤,这种损伤具有浓度和时间依赖性。

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