铜催化的 C-N 键形成/重排序列：4H-3,1-苯并恶嗪-4-酮的合成。

Copper-catalyzed C-N bond formation/rearrangement sequence: synthesis of 4H-3,1-benzoxazin-4-ones.

机构信息

College of Pharmaceutical Sciences, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China.

出版信息

J Org Chem. 2013 May 3;78(9):4524-9. doi: 10.1021/jo400515y. Epub 2013 Apr 22.

DOI:10.1021/jo400515y

PMID:23581844

Abstract

A facile and efficient copper-catalyzed method for the synthesis of 4H-3,1-benzoxazin-4-one derivatives has been developed. This procedure is based on a tandem intramolecular C-N coupling/rearrangement process. This method would provide a new and useful strategy for construction of N-heterocycles.

摘要

一种简便高效的铜催化合成 4H-3,1-苯并恶嗪-4-酮衍生物的方法已经被开发出来。该方法基于串联的分子内 C-N 偶联/重排过程。该方法为构建 N-杂环化合物提供了一种新的有用策略。