通过碘化亚铜催化，由邻卤代酚和2-卤代酰胺高效级联合成各种2H-1,4-苯并恶嗪-3-(4H)-酮。
An efficient cascade synthesis of various 2H-1,4-benzoxazin-3-(4H)-ones from o-halophenols and 2-halo-amides catalyzed by CuI.
作者信息
Chen Dingben, Shen Guodong, Bao Weiliang
机构信息
Department of Chemistry, Zhejiang University, Xi Xi Campus, Hangzhou, 310028, Zhejiang, PR China.
出版信息
Org Biomol Chem. 2009 Oct 7;7(19):4067-73. doi: 10.1039/b906210f. Epub 2009 Aug 4.
DOI:10.1039/b906210f
PMID:19763313
Abstract
A novel and efficient one-pot cascade synthesis of 2H-1,4-benzoxazin-3-(4H)-ones has been developed through copper-catalyzed coupling of o-halophenols and 2-halo-amides. Various 2H-1,4-benzoxazin-3-(4H)-ones with diversity at three substituents on their scaffold have been synthesized conveniently in good to excellent yields.
摘要
通过铜催化的邻卤代酚与2-卤代酰胺的偶联反应，开发了一种新颖高效的一锅法串联合成2H-1,4-苯并恶嗪-3-(4H)-酮的方法。各种在其骨架上具有三个不同取代基的2H-1,4-苯并恶嗪-3-(4H)-酮已以良好至优异的产率方便地合成出来。
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