Heidenkummer H P, Kampik A, Thierfelder S
Universität-Augenklinik, Würzburg.
Fortschr Ophthalmol. 1990;87(2):226-8.
The stability of intraocularly applied silicone oils plays an important role in their biocompatibility. The clinically used silicone oils are not a unique group of materials. There are important differences regarding viscosity and the amount of low molecular and ionic components. A sign of bioinstability of silicone oils is silicone oil emulsification. According to clinical experience and experimental studies, less viscous silicone oils seem to emulsify earlier then more viscous oils. Therefore, we investigated three highly purified polydimethylsiloxanes with defined physicochemical characteristics and viscosities of 1,000 cs, 5,000 cs and 10,000 cs for their in vitro stability. As detergents, we used fibrin, fibrinogen, gammaglobulins, acidic alpha-1-glycoprotein, very-low-density lipoprotein (VLDL), and serum. The oil with a viscosity of 1000 cs was the most unstable silicone oil whereas the oils of 5,000 cs and 10,000 cs reacted similarly. The most effective detergents were fibrin, fibrinogen and serum-causing emulsification for all silicone oils investigated whereas gamma-globulins, acidic alpha-1-glycoprotein and VLDL only emulsified the less viscous oil of 1,000 cs. Our results show the importance of viscosity for the stability of silicone oils and the effect of biologically potential detergents.
眼内应用硅油的稳定性在其生物相容性中起着重要作用。临床上使用的硅油并非单一的材料类别。在粘度以及低分子和离子成分的含量方面存在重要差异。硅油乳化是硅油生物不稳定性的一个迹象。根据临床经验和实验研究，粘度较低的硅油似乎比粘度较高的硅油更早发生乳化。因此，我们研究了三种具有明确理化特性、粘度分别为1000厘沲、5000厘沲和10000厘沲的高度纯化的聚二甲基硅氧烷的体外稳定性。作为去污剂，我们使用了纤维蛋白、纤维蛋白原、γ球蛋白、酸性α-1-糖蛋白、极低密度脂蛋白（VLDL）和血清。粘度为1000厘沲的硅油是最不稳定的，而5000厘沲和10000厘沲的硅油反应相似。最有效的去污剂是纤维蛋白、纤维蛋白原和血清，它们会导致所有研究的硅油发生乳化，而γ球蛋白、酸性α-1-糖蛋白和VLDL仅使粘度较低的1000厘沲的硅油发生乳化。我们的结果表明了粘度对硅油稳定性的重要性以及具有生物活性的去污剂的作用。
