Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Orthopaedics and Traumatology, Department of Orthopaedics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China.
Gene. 2013 Jul 1;523(1):58-63. doi: 10.1016/j.gene.2013.03.129. Epub 2013 Apr 10.
This study aimed to investigate the association between PASD8 gene and cancers. For 1772 C/T polymorphism (rs11549465), it included 5552 cases and 8044 controls, and for 1790 G/A (rs11549467), 3381 cases and 5830 controls. The allele-analysis results showed that 1772 C/T (rs11549465) was significantly associated with cancers (OR: 1.177, 95% CI: 1.011-1.369, p=0.035). And results of genotype-analysis indicated that 1790 G/A (rs11549467) had a significant relationship with cancers. (OR: 0.736, 95% CI: 0.595-0.910, p=0.005). For 1790 G/A (rs11549467), the association was significant when subdivided by different kinds of cancers. And no association existed when subdivided into population-type subgroups. In conclusion, PASD8 gene played an important role in the development of cancers.
本研究旨在探讨 PASD8 基因与癌症之间的关联。对于 1772 C/T 多态性（rs11549465），共纳入了 5552 例病例和 8044 例对照，对于 1790 G/A（rs11549467），纳入了 3381 例病例和 5830 例对照。等位基因分析结果显示，1772 C/T（rs11549465）与癌症显著相关（OR：1.177，95%CI：1.011-1.369，p=0.035）。基因型分析结果表明，1790 G/A（rs11549467）与癌症存在显著关系。（OR：0.736，95%CI：0.595-0.910，p=0.005）。对于 1790 G/A（rs11549467），在按不同类型癌症细分时，关联具有统计学意义。而在按人群类型亚组细分时，不存在关联。综上所述，PASD8 基因在癌症的发生发展中起着重要作用。
