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金酰胺类抗癌药物的合成与活性研究。

Gold amides as anticancer drugs: synthesis and activity studies.

机构信息

MRC Genome Damage and Stability Centre, University of Sussex, Brighton, BN1 9RQ, UK.

出版信息

Org Biomol Chem. 2013 May 21;11(19):3255-60. doi: 10.1039/c3ob27460h. Epub 2013 Apr 15.

Abstract

Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells.

摘要

模块化金酰胺化疗药物

在药物合成和发现中,获得具有强大和灵活的合成路线且易于广泛定制的现代化疗药物是关键要求。本文报道了一类具有氨基酸衍生配体的手性金酰胺配合物。它们都表现出对两种生长缓慢的乳腺癌细胞系的体外细胞毒性,对正常上皮细胞的毒性有限。

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