血管加压素与水通道蛋白-2的调节
Vasopressin and the regulation of aquaporin-2.
作者信息
Wilson Justin L L, Miranda Carlos A, Knepper Mark A
机构信息
Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr., Bldg 10, Room 6N260, Bethesda, MD, 20892-1603, USA.
出版信息
Clin Exp Nephrol. 2013 Dec;17(6):751-64. doi: 10.1007/s10157-013-0789-5. Epub 2013 Apr 13.
Abstract
Water excretion is regulated in large part through the regulation of osmotic water permeability of the renal collecting duct epithelium. Water permeability is controlled by vasopressin through regulation of the water channel, aquaporin-2 (AQP2). Two processes contribute: (1) regulation of AQP2 trafficking to the apical plasma membrane; and (2) regulation of the total amount of the AQP2 protein in the cells. Regulation of AQP2 abundance is defective in several water-balance disorders, including many polyuric disorders and the syndrome of inappropriate antidiuresis. Here we review vasopressin signaling in the renal collecting duct that is relevant to the two modes of water permeability regulation.
摘要
水排泄在很大程度上是通过调节肾集合管上皮细胞的渗透水通透性来实现的。水通透性由抗利尿激素通过调节水通道蛋白-2（AQP2）来控制。有两个过程起作用：（1）调节AQP2向顶端质膜的转运；（2）调节细胞内AQP2蛋白的总量。在几种水平衡紊乱中，包括许多多尿症和抗利尿激素分泌不当综合征，AQP2丰度的调节存在缺陷。在此，我们综述了肾集合管中与两种水通透性调节模式相关的抗利尿激素信号传导。
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