King Edward Medical University/Mayo Hospital, Pakistan.
Int J Psychiatry Med. 2012;44(3):199-210. doi: 10.2190/PM.44.3.b.
To study the prevalence of anxiety and depression symptoms in patients with dengue and to examine their correlation with symptom severity.
In this cross sectional study, 531 consecutive patients who met the World Health Organization criteria for dengue fever admitted to Mayo Hospital, Lahore between September and November 2011 were administered the Hospital Anxiety and Depression Scale (HADS). In addition to the HADS, the severity of their symptoms, like headache, myalgias/arthralgias, fever, and retro/periorbital pain, was assessed on a 3-point scale (mild, moderate, and severe).
About 60% of the patients in our study met the criteria for anxiety and 62.2% of the patients met criteria for depression. Severity of fever, headache, myalgias and arthralgias, and retro/periorbital pain was positively correlated with both anxiety (Correlation coefficients: 0.148, 0.247, 0.184, 0.184 respectively and P < 0.01 for all) and depression scores (Correlation coefficients: 0.098, 0.154, 0.131, 0.125 respectively and P value < 0.01 for all). The strongest correlation was found between severity of headache and scores for both anxiety and depression. Both mean anxiety and depression scores were significantly higher in patients with platelet count below median (30,000/mm3) than in patients with platelet count above median (9.1 +/- 4.7 vs 8.2 +/- 4.7, P < 0.03, and 9.5 +/- 4.5 vs 8.5 +/- 4.5, P < 0.01, respectively).
A majority of patients with dengue have anxiety and depression symptoms. Psychiatric evaluation should be done in all Dengue patients so timely treatment can be initiated.
研究登革热患者焦虑和抑郁症状的发生率，并探讨其与症状严重程度的相关性。
在这项横断面研究中，对 2011 年 9 月至 11 月期间在拉合尔梅奥医院符合世界卫生组织登革热标准的 531 例连续患者进行了医院焦虑和抑郁量表（HADS）评估。除 HADS 外，还对患者的症状严重程度进行了评估，包括头痛、肌痛/关节痛、发热和眼眶/眶后疼痛，评估标准为 3 分制（轻度、中度和重度）。
在我们的研究中，约 60%的患者符合焦虑标准，62.2%的患者符合抑郁标准。发热、头痛、肌痛和关节痛以及眼眶/眶后疼痛的严重程度与焦虑（相关系数分别为 0.148、0.247、0.184 和 0.184，均 P < 0.01）和抑郁评分呈正相关（相关系数分别为 0.098、0.154、0.131 和 0.125，均 P < 0.01）。头痛严重程度与焦虑和抑郁评分的相关性最强。血小板计数低于中位数（30,000/mm3）的患者的平均焦虑和抑郁评分均显著高于血小板计数高于中位数的患者（9.1 +/- 4.7 与 8.2 +/- 4.7，P < 0.03，9.5 +/- 4.5 与 8.5 +/- 4.5，P < 0.01）。
大多数登革热患者都有焦虑和抑郁症状。应该对所有登革热患者进行精神评估，以便及时进行治疗。
