Sawaguchi K, Narumiya H, Yabushita H, Noguchi M, Nakanishi M
Department of Obstetrics and Gynecology, Aichi Medical University.
Nihon Sanka Fujinka Gakkai Zasshi. 1990 Apr;42(4):313-9.
In 13 patients with ovarian cancer who had been treated with remission induction chemotherapy, we measured the levels of platelet PT, APTT, Hepa T, ATIII, alpha 2PI and FDP, and we also measured such molecular markers as fibrinopeptide A(FPA), fibrinopeptide B beta 1-42(FPB beta 1-42), and fibrinopeptide B beta 15-42 (FPB beta 15-42) before and after chemotherapy. Then the relation between the post chemotherapeutic trends of these substances and the prognosis for patient with ovarian cancer were investigated. 1) After chemotherapy, the levels of fibrinogen were increased, ATIII was decreased significantly in cases in the NC.PD group compared with the PR.CR group (p less than 0.05). The alpha 2PI concentrations were also slightly low, and the levels of FDP were within the normal range in cases in the PR.CR group, but in many cases in the NC.PD group were increased. 2) After chemotherapy, the concentrations of molecular markers (FPA, FPB beta 1-42 and FPB beta 15-42) were increased significantly in cases in the NC.PD group compared with the PR.CR group (p less than 0.05). 3) In cases in the recurrent group, the levels of ATIII and alpha 2PI were decreased significantly compared with the after therapy group, FDP, FPB beta 1-42 and FPB beta 15-42 were increased. Accordingly, the recovery of hemostatic balance with effective chemotherapy is related to the prognosis for patients with ovarian cancer, and the levels of fibrinogen, PT, alpha 2PI, ATIII, FDP, FPA, FPB beta 1-42 and FPB beta 15-42 may be able to be used in the prognosis for patients after chemotherapy.
在13例接受缓解诱导化疗的卵巢癌患者中，我们检测了血小板PT、APTT、Hepa T、ATIII、α2PI和FDP的水平，还在化疗前后检测了纤维蛋白肽A（FPA）、纤维蛋白肽Bβ1-42（FPBβ1-42）和纤维蛋白肽Bβ15-42（FPBβ15-42）等分子标志物。然后研究了这些物质化疗后的变化趋势与卵巢癌患者预后的关系。1）化疗后，NC.PD组患者的纤维蛋白原水平升高，ATIII水平较PR.CR组显著降低（p<0.05）。α2PI浓度也略低，PR.CR组患者的FDP水平在正常范围内，但NC.PD组的许多患者FDP水平升高。2）化疗后，NC.PD组患者的分子标志物（FPA、FPBβ1-42和FPBβ15-42）浓度较PR.CR组显著升高（p<0.05）。3）复发组患者的ATIII和α2PI水平较治疗后组显著降低，FDP、FPBβ1-42和FPBβ15-42升高。因此，有效的化疗使止血平衡的恢复与卵巢癌患者的预后相关，纤维蛋白原、PT、α2PI、ATIII、FDP、FPA、FPBβ1-42和FPBβ15-42水平可能可用于化疗后患者的预后评估。
