ω-3 脂肪酸补充剂可降低癫痫大鼠的静息心率。
Omega-3 fatty acid supplementation reduces resting heart rate of rats with epilepsy.
机构信息
Disciplina de Neurologia Experimental, Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, Brazil.
出版信息
Epilepsy Behav. 2013 Jun;27(3):504-6. doi: 10.1016/j.yebeh.2013.02.017. Epub 2013 Apr 12.
Since cardiovascular dysfunction may contribute to sudden unexpected death in epilepsy (SUDEP), the consumption of omega-3 fatty acids (omega-3 FAs) might be beneficial as an adjunctive therapy for SUDEP prevention. It is well recognized that omega-3 FAs exert positive effects on the cardiovascular system including heart rate (HR) reduction, a major risk factor to sudden death. Thus, we evaluated the effects of chronic supplementation of omega-3 FAs on the HR of rats with epilepsy. In agreement with our previous investigations, this study also showed that the HR of animals with epilepsy is higher than that of the control group. Quite interestingly, chronic supplementation with omega-3 FAs restored the HR of rats with epilepsy toward control values. In conclusion, although further investigations are still required, our preliminary results showed a potential preventive effect of omega-3 FA supplementation against SUDEP.
由于心血管功能障碍可能导致癫痫猝死（SUDEP），因此，ω-3 脂肪酸（ω-3 FAs）的消耗可能作为预防 SUDEP 的辅助治疗有益。众所周知，ω-3 FAs 对心血管系统具有积极作用，包括降低心率（HR），这是猝死的主要危险因素。因此，我们评估了慢性补充 ω-3 FAs 对癫痫大鼠 HR 的影响。与我们之前的研究一致，本研究还表明，癫痫动物的 HR 高于对照组。有趣的是，慢性补充 ω-3 FAs 使癫痫大鼠的 HR 恢复到对照值。总之，尽管还需要进一步的研究，但我们的初步结果显示 ω-3 FA 补充可能对预防 SUDEP 有潜在的作用。
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