CCR7/CCL19/CCL21 趋化因子轴在适应性免疫系统中的众多功能和复杂调控。
A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system.
机构信息
The Chemokine Biology Laboratory, School of Molecular and Biomedical Science, University of Adelaide, Australia.
出版信息
Cytokine Growth Factor Rev. 2013 Jun;24(3):269-83. doi: 10.1016/j.cytogfr.2013.03.001. Epub 2013 Apr 12.
The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of T cells and DCs to T cell areas of lymphoid tissues where T cell priming occurs. However, CCR7 and its ligands also contribute to a multitude of adaptive immune functions including thymocyte development, secondary lymphoid organogenesis, high affinity antibody responses, regulatory and memory T cell function, and lymphocyte egress from tissues. In this survey, we summarise the role of CCR7 in adaptive immunity and describe recent progress in understanding how this axis is regulated. In particular we highlight CCX-CKR, which scavenges both CCR7 ligands, and discuss its emerging significance in the immune system.
趋化因子受体 CCR7 及其配体 CCL19 和 CCL21 控制适应性免疫功能中的多种迁移事件。最突出的是，CCR7 促进 T 细胞和 DC 向发生 T 细胞启动的淋巴组织的 T 细胞区归巢。然而，CCR7 和其配体也有助于多种适应性免疫功能，包括胸腺细胞发育、次级淋巴器官发生、高亲和力抗体反应、调节性和记忆性 T 细胞功能以及淋巴细胞从组织中迁出。在本综述中，我们总结了 CCR7 在适应性免疫中的作用，并描述了近年来对该轴如何被调控的理解进展。特别是，我们强调了趋化因子 CXC-CKR，它清除了两种 CCR7 配体，并讨论了其在免疫系统中的新兴意义。
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