College of Medicine and Medical Research Institute, Chungbuk National University, 12 Gaeshin-Dong Henugduk-Ku, Cheongju 361-763, Republic of Korea.
Antiviral Res. 2013 Jun;98(3):386-93. doi: 10.1016/j.antiviral.2013.04.006. Epub 2013 Apr 13.
Herbal medicine is used to treat many conditions such as asthma, eczema, premenstrual syndrome, rheumatoid arthritis, migraine, headaches, menopausal symptoms, chronic fatigue, irritable bowel syndrome, cancer, and viral infections such as influenza. In this study, we investigated the antiviral effect of KIOM-C for the treatment of influenza A virus infection. Our results show that oral administration of KIOM-C conferred a survival benefit to mice infected with the 2009 pandemic H1N1 [A(H1N1)pdm09] virus, and resulted in a 10- to 100-fold attenuation of viral replication in ferrets in a dose-dependent manner. Additionally, oral administration of KIOM-C increased the production of antiviral cytokines, including IFN-γ and TNF-α, and decreased levels of pro-inflammatory cytokines (IL-6) and chemokines (KC, MCP-1) in the Bronchoalveolar lavage fluid (BALF) of A(H1N1)pdm-infected mice. These results indicate that KIOM-C can promote clearance of influenza virus in the respiratory tracts of mice and ferrets by modulating cytokine production in hosts. Taken together, our results suggest that KIOM-C is a potential therapeutic compound mixture for the treatment of influenza virus infection in humans.
草药被用于治疗多种疾病，如哮喘、湿疹、经前综合征、类风湿性关节炎、偏头痛、头痛、更年期症状、慢性疲劳、肠易激综合征、癌症和流感等病毒感染。在这项研究中，我们研究了 KIOM-C 治疗甲型流感病毒感染的抗病毒作用。我们的结果表明，KIOM-C 的口服给药可使感染 2009 年大流行性 H1N1 [A(H1N1)pdm09]病毒的小鼠受益于生存，并以剂量依赖性方式使雪貂中的病毒复制减少 10 至 100 倍。此外，KIOM-C 的口服给药增加了抗病毒细胞因子（包括 IFN-γ和 TNF-α）的产生，并降低了 A（H1N1）pdm 感染小鼠支气管肺泡灌洗液（BALF）中促炎细胞因子（IL-6）和趋化因子（KC，MCP-1）的水平。这些结果表明，KIOM-C 通过调节宿主中的细胞因子产生，可以促进小鼠和雪貂呼吸道中流感病毒的清除。总之，我们的结果表明，KIOM-C 是一种用于治疗人类流感病毒感染的潜在治疗性复方混合物。
