Kouyoumdjian João Aris, Stålberg Erik
Department of Neurological Sciences, Neuromuscular Investigation Laboratory, São Paulo SP, Brazil.
Arq Neuropsiquiatr. 2013 Apr;71(4):237-43. doi: 10.1590/0004-282x20130008.
To estimate jitter parameters in myasthenia gravis in stimulated frontalis and extensor digitorum muscles using the concentric needle electrode.
Forty-two confirmed myasthenia gravis patients, being 22 males (aged 45.6±17.2 years-old) were studied. Jitter was expressed as the mean consecutive difference (MCD).
MCD in extensor digitorum was 61.6 µs (abnormal in 85.7%) and in frontalis 57.3 µs (abnormal in 88.1%). Outliers represented 90.5% for extensor digitorum and 88.1% for frontalis. At least one jitter parameter was abnormal in 90.5% of the combined studies. Acetylcholine receptor antibody was abnormal in 85.7% of the cases.
Stimulated jitter recordings measured from muscles using concentric needle electrode can be used for myasthenia gravis diagnosis with high sensitivity. Extensive normative studies are still lacking and, therefore, borderline findings should be judged with great caution.
使用同心针电极评估重症肌无力患者受刺激的额肌和指伸肌的抖动参数。
对42例确诊的重症肌无力患者进行研究，其中男性22例（年龄45.6±17.2岁）。抖动以平均连续差值（MCD）表示。
指伸肌的MCD为61.6微秒（85.7%异常），额肌的MCD为57.3微秒（88.1%异常）。指伸肌的异常值占90.5%，额肌的异常值占88.1%。在联合研究中，90.5%的患者至少有一项抖动参数异常。85.7%的病例乙酰胆碱受体抗体异常。
使用同心针电极从肌肉测量的受刺激抖动记录可用于重症肌无力的诊断，具有高灵敏度。目前仍缺乏广泛的正常对照研究，因此，对于临界结果应谨慎判断。
