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两种常用处方药相互作用后出现危及生命的横纹肌溶解症。

Life-threatening rhabdomyolysis following the interaction of two commonly prescribed medications.

作者信息

Fallah Alireza, Deep Maitri, Smallwood David, Hughes Peter

机构信息

Box Hill Hospital, Department of General Medicine.

出版信息

Australas Med J. 2013 Mar 31;6(3):112-4. doi: 10.4066/AMJ.2013.1616. Print 2013.

DOI:10.4066/AMJ.2013.1616
PMID:23589735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3626026/
Abstract

We report an interaction between erythromycin and simvastatin resulting in life-threatening rhabdomyolysis in an elderly patient. Drugs that inhibit CYP3A4 enzyme can cause elevated serum levels of statins which amplifies the risk of statin-induced rhabdomyolysis. Physicians should be aware of potential drug interactions of statins, which are widely used in the community.

摘要

我们报告了一例老年患者中红霉素与辛伐他汀相互作用导致危及生命的横纹肌溶解症。抑制CYP3A4酶的药物可导致他汀类药物血清水平升高，从而增加他汀类药物诱发横纹肌溶解症的风险。医生应意识到他汀类药物在社区中广泛使用时潜在的药物相互作用。

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本文引用的文献

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TGA and -back to the future (take 2).完全性大动脉转位与——回到未来（第二幕）。
Aust Prescr. 2024 Feb;47(1):29. doi: 10.18773/austprescr.2024.003.
2
Rhabdomyolysis following clarithromycin monotherapy.克拉霉素单药治疗后发生横纹肌溶解症。
Am J Med Sci. 2009 Jul;338(1):78. doi: 10.1097/MAJ.0b013e31819e221f.
3
Co-medication of statins and CYP3A4 inhibitors before and after introduction of new reimbursement policy.新报销政策出台前后他汀类药物与CYP3A4抑制剂的联合用药情况。
Br J Clin Pharmacol. 2009 Feb;67(2):234-41. doi: 10.1111/j.1365-2125.2008.03345.x. Epub 2009 Feb 9.
4
Risk management of simvastatin or atorvastatin interactions with CYP3A4 inhibitors.辛伐他汀或阿托伐他汀与CYP3A4抑制剂相互作用的风险管理。
Drug Saf. 2008;31(7):587-96. doi: 10.2165/00002018-200831070-00004.
5
Clinical perspectives of statin-induced rhabdomyolysis.他汀类药物所致横纹肌溶解症的临床观点
Am J Med. 2006 May;119(5):400-9. doi: 10.1016/j.amjmed.2006.02.007.
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Drug-induced rhabdomyolysis after concomitant use of clarithromycin, atorvastatin, and lopinavir/ritonavir in a patient with HIV.一名HIV患者同时使用克拉霉素、阿托伐他汀和洛匹那韦/利托那韦后发生药物性横纹肌溶解症。
AIDS Patient Care STDS. 2003 May;17(5):207-10. doi: 10.1089/108729103321655854.