Center for Systems Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Curr Top Med Chem. 2013;13(8):920-35. doi: 10.2174/1568026611313080005.
The development of tropane-derivatives as cocaine-addiction therapeutics identified numerous compounds with affinities for the dopamine, serotonin, and norepinephrine transporters. Many of these compounds were then adapted for use as imaging radiotracers. Incorporation of fluorine into the molecule often improved the physiochemical properties of the compound and also provided a position for radiolabeling with fluorine-18. This review provides an overview of the efforts devoted to developing fluorine-18 radiolabeled tropanes for imaging use with positron emission tomography.
作为可卡因成瘾治疗药物，托烷类衍生物的开发确定了许多对多巴胺、血清素和去甲肾上腺素转运体具有亲和力的化合物。其中许多化合物随后被改编为成像示踪剂。将氟原子引入分子中通常可以改善化合物的物理化学性质，并为用氟-18 进行放射性标记提供了一个位置。本综述概述了开发用于正电子发射断层扫描成像的氟-18 放射性标记托烷类化合物的努力。
